193902-81-7

Basic information

• Product Name: 4-(4-Boc-piperazin-1-yl)-3-chloroaniline
• Synonyms: 4-(4-Boc-piperazin-1-yl)-3-chloroaniline;tert-butyl 4-(4-amino-2-chlorophenyl)piperazine-1-carboxylate
• CAS NO: 193902-81-7
• Molecular Formula: C₁₅H₂₂ClN₃O₂
• Molecular Weight: 311.81
• Mol File: 193902-81-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 467.3 °C at 760 mmHg
• Flash Point: 236.4 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 6.57E-09mmHg at 25°C
• Refractive Index: 1.574
• PKA: 6.63±0.10(Predicted)
• CAS DataBase Reference: 4-(4-Boc-piperazin-1-yl)-3-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Boc-piperazin-1-yl)-3-chloroaniline(193902-81-7)
• EPA Substance Registry System: 4-(4-Boc-piperazin-1-yl)-3-chloroaniline(193902-81-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 193902-81-7(Hazardous Substances Data)

Usage

General Description

The chemical 4-(4-Boc-piperazin-1-yl)-3-chloroaniline is a compound with a molecular formula C16H24ClN3O2. It is a derivative of piperazine and aniline, containing a Boc (tert-butoxycarbonyl) protective group on the piperazine nitrogen and a chlorine atom on the aniline ring. 4-(4-Boc-piperazin-1-yl)-3-chloroaniline is commonly used in organic and medicinal chemistry research as a building block for the synthesis of various pharmaceuticals and biologically active molecules. Its specific structure and functional groups make it a valuable intermediate in the preparation of diverse chemical compounds.

InChI:InChI=1/C15H22ClN3O2/c1-15(2,3)21-14(20)19-8-6-18(7-9-19)13-5-4-11(17)10-12(13)16/h4-5,10H,6-9,17H2,1-3H3

Upstream product

• 193902-80-6 tert-butyl 4-(2-chloro-4-nitro-phenyl)piperazine-1-carboxylate 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 29682-39-1 1-bromo-2-chloro-4-nitrobenzene 

Downstream Products

• 850628-96-5 4-[2-chloro-4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1185844-89-6 C₂₅H₃₂ClN₃O₃ 

Relevant articles and documents

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER

The invention provides compounds of the formula (1): or a salt or tautomer thereof wherein A, R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are inhibitors of Wee1 and/or PLK1 kinase and are envisaged to be useful in the treatment of cancers.

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X1~X5, R1~R3, A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists

A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.