193902-80-6

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-(2-chloro-4-nitrophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 193902-80-6
• Molecular Formula: C15H20ClN3O4
• Molecular Weight: 341.794
• Mol File: 193902-80-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-(2-chloro-4-nitrophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-(2-chloro-4-nitrophenyl)-, 1,1-dimethylethyl ester(193902-80-6)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-(2-chloro-4-nitrophenyl)-, 1,1-dimethylethyl ester(193902-80-6)

Safety Data

• Hazardous Substances Data: 193902-80-6(Hazardous Substances Data)

Usage

Physical form

White to light yellow crystalline powder

Usage

Commonly used as a starting material in the synthesis of various pharmaceuticals and agrochemicals

Biological activities

Diverse range of biological activities, including antimicrobial, antiparasitic, and antitumor properties

Applications

Used in the synthesis of anti-inflammatory and analgesic drugs, as well as pesticides

Industrial importance

Utilized as an intermediate in the production of various dyes and pigments

Significance

An important chemical in the pharmaceutical and agrochemical industries due to its versatility and wide range of applications.

Upstream product

• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 182618-86-6 tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 41252-96-4 3-chloro-4-iodonitrobenzene 
• 29682-39-1 1-bromo-2-chloro-4-nitrobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114878-60-3 1-(2-chloro-4-nitro-phenyl)piperazine 

Downstream Products

• 701220-40-8 1-(4-(4-amino-2-chlorophenyl)piperazin-1-yl)-2-methylpropan-1-one 
• 850628-96-5 4-[2-chloro-4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 193902-81-7 4-(4-amino-2-chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER

The invention provides compounds of the formula (1): or a salt or tautomer thereof wherein A, R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are inhibitors of Wee1 and/or PLK1 kinase and are envisaged to be useful in the treatment of cancers.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

The identification of a series of novel, soluble non-peptidic neuropeptide y Y2 receptor antagonists

The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.