193902-86-2

Basic information

• Product Name: TERT-BUTYL 4-(2-METHYL-4-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-(2-METHYL-4-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE;tert-butyl 4-(4-nitro-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate;tert-butyl 4-(4-nitro-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate（WS204198）
• CAS NO: 193902-86-2
• Molecular Formula: C₁₆H₂₀F₃N₃O₄
• Molecular Weight: 321.37152
• Mol File: 193902-86-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL 4-(2-METHYL-4-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(2-METHYL-4-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE(193902-86-2)
• EPA Substance Registry System: TERT-BUTYL 4-(2-METHYL-4-NITROPHENYL)PIPERAZINE-1-CARBOXYLATE(193902-86-2)

Safety Data

• Hazardous Substances Data: 193902-86-2(Hazardous Substances Data)

Upstream product

• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 

Downstream Products

• 381242-61-1 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine 

Relevant articles and documents

NOVEL INHIBITORS OF MAP4K1

The invention relates to novel inhibitors of MAP4K1 (HPK1) useful for the treatment of diseases or disorders characterised by dysregulation of the signal transduction pathways associated with MAPK activation, including hyperproliferative diseases, diseases of immune system dysfunction, inflammatory disorders, neurological diseases, and cardiovascular diseases. The invention further relates to pharmaceutical compositions comprising the same and methods of treatment of said diseases and disorders. The inhibitors are of formula (I) wherein the definitions for A, D, E, F, R5, R6, R7, Z, ring Q, n, x and y are as given in the application.

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X1~X5, R1~R3, A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.

IMIDAZOQUINOLINES AS LIPID KINASE INHIBITORS

The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.