193904-48-2Relevant academic research and scientific papers
[FeIII(F20-tpp)Cl] Is an effective catalyst for nitrene transfer reactions and animation of saturated hydrocarbons with sulfonyl and aryl azides as nitrogen source under thermal and microwave-assisted conditions
Liu, Yungen,Che, Chi-Ming
experimental part, p. 10494 - 10501 (2010/10/21)
[FeIII(F20-tpp)Cl] (F20tpp = meso- tetrakis(pentafluorophenyl)porphyrinato dianion) is an effective catalyst for imido/nitrene insertion reactions using sulfonyl and aryl azides as nitrogen source. Under thermal conditions, aziridination of aryl and alkyl alkenes (16 examples, 60-95% yields), sulfimidation of sulfides (11 examples, 76-96% yields), allylic amidation/amination of α-methylstyrenes (15 examples, 68-83% yields), and amination of saturated C-H bonds including that of cycloalkanes and adamantane (eight examples, 64-80% yields) can be accomplished by using 2 mol % [FeIII(F20- tpp)Cl] as catalyst. Under microwave irradiation conditions, the reaction time of aziridination (four examples), allylic amination (five examples), sulfimidation (two examples), and amination of saturated C-H bonds (three examples) can be reduced by up to 16fold (24-48 versus 1.5-6 h) without significantly affecting the product yield and substrate conversion.
N2-Benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1, 2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor
Kessler, Albane,Faure, Hélène,Petrel, Christophe,Ruat, Martial,Dauban, Philippe,Dodd, Robert H.
, p. 3345 - 3349 (2007/10/03)
The synthesis and calcimimetic activities of two new families of compounds are described. The most active derivatives of the first family, N 2-(2-chloro-(or 4-fluoro-)benzyl)-N1-(1-(1-naphthyl)ethyl) -3-phenylpropane-1,2-diamine (4b
N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor
Dauban, Philippe,Ferry, Sandrine,Faure, Hélène,Ruat, Martial,Dodd, Robert H.
, p. 2001 - 2004 (2007/10/03)
The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 μM) produced 974±11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd.
Preparation and evaluation of nitrene precursors (PhI=NSO2Ar) for the copper-catalyzed aziridination of olefins
Soedergren, Mikael J.,Alonso, Diego A.,Bedekar, Ashutosh V.,Andersson, Pher G.
, p. 6897 - 6900 (2007/10/03)
The preparation of different [N-(arenesulfonyl)imino]phenyliodinanes is described along with an evaluation of their utility as nitrene precursors for the copper-catalyzed aziridination of different olefins. The best results were obtained with p-NO2/
