339570-27-3Relevant academic research and scientific papers
N2-Benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1, 2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor
Kessler, Albane,Faure, Hélène,Petrel, Christophe,Ruat, Martial,Dauban, Philippe,Dodd, Robert H.
, p. 3345 - 3349 (2007/10/03)
The synthesis and calcimimetic activities of two new families of compounds are described. The most active derivatives of the first family, N 2-(2-chloro-(or 4-fluoro-)benzyl)-N1-(1-(1-naphthyl)ethyl) -3-phenylpropane-1,2-diamine (4b
N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor
Dauban, Philippe,Ferry, Sandrine,Faure, Hélène,Ruat, Martial,Dodd, Robert H.
, p. 2001 - 2004 (2007/10/03)
The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 μM) produced 974±11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd.
