19391-85-6

Upstream product

• 117-39-5 quercetol 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 82546-95-0 2,2',2''-((2-(3,4-bis(carboxymethoxy)phenyl)-4-oxo-4H-chromene-3,5,7-triyl)tris(oxy))triacetic acid 

Relevant academic research and scientific papers

Novel quercetin and apigenin-acetamide derivatives: Design, synthesis, characterization, biological evaluation and molecular docking studies

Flavonoids exhibit essential but limited biological properties which can be enhanced through chemical modifications. In this study, we designed, synthesized, and characterized two novel flavonoid derivatives, quercetin penta-acetamide (1S3) and apigenin t

Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain

Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis. They inhibit more potently the particulate enzyme than the cytosolic preparation. The highest selectivity was observed with penta-O-ethylquercetin and analogue 6d, which proved to be more selective and more potent inhibitors than the reference compound Ro 20-1724. Some structure-activity relationships are discussed.