19394-08-2Relevant academic research and scientific papers
Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers
Ebrahimi, Edris,Jarrahpour, Aliasghar,Heidari, Nahid,Sinou, Véronique,Latour, Christine,Brunel, Jean M.,Zolghadr, Amin R.,Turos, Edward
, p. 247 - 262 (2016/01/25)
This report describes the preparation of some new β-lactam nanocopolymers. These nanoparticles are synthesized in water by emulsion polymerization of an acrylate β-lactam pre-dissolved in a mixture of co-monomers in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 30-70 nm in diameter. These compounds have been evaluated for their antimalarial activities against chloroquine-resistant Plasmodium faliparum K1 strain demonstrating IC50 varying from 14 to 50 μM. The interactions between these β-lactam nanocopolymers and the P. falciparum single-stranded DNA-binding proteins have been studied by molecular docking calculations.
Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
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Page/Page column 75; 76, (2015/09/23)
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
An efficient microwave method for the synthesis of imines
Border, Emily C.,Blair, Victoria L.,Andrews, Philip C.
, p. 844 - 848 (2015/05/20)
A large variety of aryl and heterocyclic chiral and achiral imines can be generated simply, efficiently, and cleanly through the use of microwave irradiation and the use of a small amount of molecular sieve. Reactions are rapid and complete in a matter of minutes, and can be quantitative, reducing significantly the time and amount of solvents used in compound isolation and purification.
Synthesis of oligosaccharide determinants with amide spacers of T-type antigens
Paulsen,Jacquinet,Rust
, p. 195 - 219 (2007/10/02)
The hapten of the T-antigen was synthesized with a peptide-like amide-spacer as 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside and coupled with serum albumin to give a synthetic antigen. Other O-beta-D-galactopyranosyl haptens, 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-4-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, O-beta-D-galactopyranosyl-(1 leads to 3)-O-[beta-D-galactopyranosyl-(1 leads to 4)]-2-acetamido-2-deoxy-alpha-D-galactopyranoside, and 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside, the last compound being the determinant of the Lewis Lec antigen, were also synthesized.
REACTION OF 2-(ARYLIDENEAMINO)ETHANOLS WITH CARBONYL COMPOUNDS
Letunov, V. I.
, p. 2152 - 2154 (2007/10/02)
With acetophenone and p-nitroacetophenone in the presence of catalytic amounts of acid 2-(arylideneamino)ethanols form α,β-unsaturated ketones, and with antipyrine they form products from addition at the azomethine bond.
NEW PESTICIDES AND INTERMEDIATES. PART V. TRANSFORMATION OF N-(FORMYLPHENYL)CARBAMATES INTO SUBSTITUTED OXAZOLIDINE-1,3 SYSTEM
Witek, Stanislaw,Bielawska, Alicja,Bielawski, Jacek
, p. 2025 - 2030 (2007/10/02)
A reaction of N-(4-formylphenyl)carbamates (1) with ethanolamine leads to a pseudomeric system of N-(2-hydroxyethyl)-4'-alkoxycarbaminobenzylideneimines (3), and undetectable (TLC, NMR) oxazolidines-1,3 (4).A subsequent reaction of the system with isocyanates results in exclusively urea derivatives of oxazolidine (5 and 6).This fact univocally confirms the tautomeric equilibrium of 34 system.All compounds obtained (3,5,6,8,9) were subjected to biological tests in order to elucidate their activity.
