19394-08-2

Basic information

• Product Name: 2-{[(E)-(4-nitrophenyl)methylidene]amino}ethanol
• CAS NO: 19394-08-2
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 19394-08-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 358°C at 760 mmHg
• Flash Point: 170.3°C
• Density: 1.24g/cm³
• Vapor Pressure: 9.5E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 2-{[(E)-(4-nitrophenyl)methylidene]amino}ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(E)-(4-nitrophenyl)methylidene]amino}ethanol(19394-08-2)
• EPA Substance Registry System: 2-{[(E)-(4-nitrophenyl)methylidene]amino}ethanol(19394-08-2)

Safety Data

• Hazardous Substances Data: 19394-08-2(Hazardous Substances Data)

Usage

Description

Organic compound containing a nitrophenyl group and an amine group connected to an ethanol backbone.

Appearance

Yellow solid

Molecular Weight

208.21 g/mol

Potential Uses

Pharmaceutical and chemical industries

Biological Activity

Known for potential biological activity, making it a subject of interest for medicinal chemistry research.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 141-43-5 ethanolamine 

Downstream Products

• 84905-12-4 4-[(2-Hydroxy-ethylamino)-(4-nitro-phenyl)-methyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 25870-67-1 1,3-bis(4-nitrophenyl)prop-2-en-1-one 
• 1222-98-6 4-nitrochalcone 
• 91092-28-3 3-dichloroacetyl-2-(4-nitro-phenyl)-oxazolidine 
• 1016237-77-6 t-butyl [(2-bromo-ethyl)-(4-nitro-benzyl)-amino]acetate 
• 1016237-75-4 t-butyl [(2-hydroxy-ethyl)-(4-nitro-benzyl)-amino]acetate 
• 64834-64-6 2-(4-nitrobenzylbenzylamino)ethanol 

Relevant articles and documents

Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers

This report describes the preparation of some new β-lactam nanocopolymers. These nanoparticles are synthesized in water by emulsion polymerization of an acrylate β-lactam pre-dissolved in a mixture of co-monomers in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 30-70 nm in diameter. These compounds have been evaluated for their antimalarial activities against chloroquine-resistant Plasmodium faliparum K1 strain demonstrating IC50 varying from 14 to 50 μM. The interactions between these β-lactam nanocopolymers and the P. falciparum single-stranded DNA-binding proteins have been studied by molecular docking calculations.

An efficient microwave method for the synthesis of imines

A large variety of aryl and heterocyclic chiral and achiral imines can be generated simply, efficiently, and cleanly through the use of microwave irradiation and the use of a small amount of molecular sieve. Reactions are rapid and complete in a matter of minutes, and can be quantitative, reducing significantly the time and amount of solvents used in compound isolation and purification.

Synthesis of oligosaccharide determinants with amide spacers of T-type antigens

The hapten of the T-antigen was synthesized with a peptide-like amide-spacer as 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside and coupled with serum albumin to give a synthetic antigen. Other O-beta-D-galactopyranosyl haptens, 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-4-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, O-beta-D-galactopyranosyl-(1 leads to 3)-O-[beta-D-galactopyranosyl-(1 leads to 4)]-2-acetamido-2-deoxy-alpha-D-galactopyranoside, and 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside, the last compound being the determinant of the Lewis Lec antigen, were also synthesized.