19395-07-4Relevant academic research and scientific papers
SYNTHESES OF (+)- AND (-)-MELLEIN UTILIZING AN ANNELATION REACTION OF ISOXAZOLES WITH DIMETHYL 3-OXOGLUTARATE
Takeuchi, Naoki,Goto, Kaori,Sasaki, Yuki,Fujita, Takashi,Okazaki, Kohsuke,et al.
, p. 357 - 374 (2007/10/02)
Naturally occurring dihydroisocoumarins, (+)- and (-)-mellein (2 and 3), metabolites of fungals, Cercospora sp. and Aspergillus sp., etc., were synthesized from the isoxazoles (32) and (33) by the annelation reactions with dimethyl 3-oxoglutarate.
