42457-27-2

Upstream product

• 75513-43-8 1-(dimethylamino)-5-phenylpenta-1,4-dien-3-on 
• 37401-88-0 (E)-1-phenyl-1-penten-4-yn-3-one 
• 64-17-5 ethanol 
• 93315-26-5 5-(phenylimino-(ξ))-1t-phenyl-penten-(1)-one-(3) 
• 85167-83-5 diethyl(5-isoxazolylmethyl)phosphonate 
• 100-52-7 benzaldehyde 
• 113351-96-5 (5-isoxazolylmethyl)-triphenylphosphonium bromide 

Downstream Products

• 90252-91-8 dimethyl 2-hydroxy-4-(2-phenylethenyl)-1,3-benzenedicarboxylate 
• 19395-07-4 (1E,4Z)-1-Amino-5-phenyl-penta-1,4-dien-3-one 

Relevant academic research and scientific papers

TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3

A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3via a radical mechanism process is described. This methodology provides an easy access to a variety of useful 5-substituted isoxazoles

SYNTHESES OF (+)- AND (-)-MELLEIN UTILIZING AN ANNELATION REACTION OF ISOXAZOLES WITH DIMETHYL 3-OXOGLUTARATE

Naturally occurring dihydroisocoumarins, (+)- and (-)-mellein (2 and 3), metabolites of fungals, Cercospora sp. and Aspergillus sp., etc., were synthesized from the isoxazoles (32) and (33) by the annelation reactions with dimethyl 3-oxoglutarate.