19396-77-1

Upstream product

• 1004-36-0 2,6-dimethylpyrone 
• 108-24-7 acetic anhydride 
• 75-44-5 phosgene 
• 91950-53-7 3,3'-disulfanediyl-bis-pentane-2,4-dione bis-(3,4-enol tautomer) 
• 123-54-6 acetylacetone 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 77600-94-3 1,3-Diacetyl-2-hydroxy-6-methyl-4-pyrrolidino-benzol 
• 77600-95-4 1,3-Diacetyl-2-hydroxy-6-methyl-4-(4-morpholino)-benzol 
• 79512-46-2 1,1',3,3'-Tetraacetyl-2,2'-dihydroxy-6,6'-dimethyl-4,4'-(1,4-piperazindiyl)-bis-benzol 
• 79512-33-7 1,3-Diacetyl-2-hydroxy-6-methyl-4-(1,2,3,4-tetrahydroisochinolino)-benzol 
• 77222-75-4 2,6-Diacetyl-5-hydroxy-5-methyl-3-(1,2,3,4-tetrahydroisochinolino)-2-cyclohexen-1-on 
• 85450-67-5 3-Acetyl-2-hydroxy-4,6-dimethyl-5-nitro-acetophenon 
• 1004-36-0 2,6-dimethylpyrone 
• 79512-32-6 1,3-Diacetyl-2-hydroxy-6-methyl-4-(4-cyano-4-phenyl-piperidino)-benzol 
• 79512-31-5 1,3-Diacetyl-2-hydroxy-6-methyl-4-(4-benzylpiperidino)-benzol 
• 79512-34-8 1,3-Diacetyl-2-hydroxy-6-methyl-4-(1-perhydroazepino)-benzol 
• 77222-74-3 2,6-Diacetyl-5-hydroxy-5-methyl-3-perhydroazepino-2-cyclohexen-1-on 
• 77222-73-2 2,6-Diacetyl-5-hydroxy-5-methyl-3-piperidino-2-cyclohexen-1-on 
• 77600-93-2 1,3-Diacetyl-2-hydroxy-6-methyl-4-piperidino-benzol 

Relevant academic research and scientific papers

Unusual aluminum chloride-assisted conversion of isopropenyl acetate into 3-acetyl- and 3,5-diacetyl-2,6-dimethyl-4H-pyran-4-ones

Reflux of isopropenyl acetate with an excess of AlCl3 in 1,2-dichloroethane affords 3,5-diacetyl-2,6-dimethyl-4H-pyran-4-one in 17% yield. The mild acidic cleavage of the latter (2% HCl, 20°C, 16 h) gives 3-acetyl-2,6-dimethyl-4H-pyran-4-one in 87% yield, whereas this reaction under more drastic conditions (17% HCl, reflux, 3 h) gives 2,6-dimethyl-4H-pyran-4-one in 61% yield.

Convenient Syntheses of Alkyl β-Resorcylate Derivatives

Syntheses of methyl 2,4-dihydroxy-6-methyl- (1a) and -3,6-dimethylbenzoates (1b) and methyl 2,4-dihydroxy-6-pentylbenzoate (1c) are described.Condensation reactions of dimethyl sodiomalonate with the dianion derived from pentane-2,4-dione or the dimerisation of the methyl acetoacetate dianion or the acetylation of the trianion derived from methyl 3,5,7-trioxo-octanoate gave (1a) (78percent) after work-up at pH 9.Analogous convenient, short, optimised syntheses of (1b and c) are given in detail.