1940-02-9

Upstream product

• 56-23-5 tetrachloromethane 
• 506-68-3 bromocyane 
• 75-52-5 nitromethane 
• 79-01-6 Trichloroethylene 
• 98-95-3 nitrobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 75-05-8 acetonitrile 
• 1821-12-1 4-Phenylbutyric acid 

Downstream Products

• 62757-98-6 (3aS)-3c-(4-phenyl-butyryloxy)-2t-(4-phenyl-butyryloxymethyl)-(3ar,9ac)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-ylideneamine 
• 64353-78-2 4-phenyl-butyric acid cyclohexylamide 
• 3173-53-3 Cyclohexyl isocyanate 
• 1821-12-1 4-Phenylbutyric acid 
• 591-50-4 iodobenzene 
• 2046-17-5 methyl 3-(benzyl)propanoate 

Relevant academic research and scientific papers

Photochemical Asymmetric Nickel-Catalyzed Acyl Cross-Coupling

Photochemical enantioselective nickel-catalyzed cross-coupling reactions are difficult to implement. We report a visible-light-mediated strategy that successfully couples symmetrical anhydrides and 4-alkyl dihydropyridines (DHPs) to afford enantioenriched α-substituted ketones under mild conditions. The chemistry does not require exogenous photocatalysts. It is triggered by the direct excitation of DHPs, which act as a radical source and as a reductant, facilitating the turnover of the chiral catalytic nickel complex.

Pt(IV) PRODRUGS

The invention provides a novel class of Pt-based anticancer compounds exhibiting multiple anticancer activity.

METHOD FOR PRODUCING CARBOXYLIC ANHYDRIDE AND ARYLBORONIC ACID COMPOUND

When phthalic acid is heated in heptane under azeotropic reflux conditions in the presence of a catalytic amount of an arylboronic acid compound (such as 2,6-(diisopropylaminomethyl)phenylboronic acid or 2,6-bis(diisopropylaminomethyl)phenylboronic acid), phthalic anhydride is obtained in high yield.

Bronsted base-assisted boronic acid catalysis for the dehydrative intramolecular condensation of dicarboxylic acids

Bronsted base-assisted boronic acid catalysis for the dehydrative self-condensation of carboxylic acids is described. Arylboronic acid bearing bulky (N,N-dialkylamino)methyl groups at the 2,6-positions can catalyze the intramolecular dehydrative condensation of di-and tetracarboxylic acids. This is the first successful method for the catalytic dehydrative self-condensation of carboxylic acids.(Figure Presented)

Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids

We report the preparation of combinatorial libraries which consist of derivatives of the stereoisomeric alkaloids yohimbine and rauwolscine- members of the Rauwolfia genus. The chemistry was performed on solid support using the divide-and-pool method, and involved the derivatization of the E- ring carboxylates and hydroxyls of these alkaloids with 36 amino acids and 22 carboxylic acids, respectively, to afford 792 bifunctionalized derivatives. The rauwolscine library was prepared using an encoding strategy in which the identity of each incorporated amino acid was recorded by cosynthesizing chemically inert tags prior to the pooling step. The general strategy for library synthesis exploits existing functionality present on the natural products, and should be applicable to other families of secondary metabolites.

Reactions of Carboxylic Acids with "Phosphonium Anhydrides"

General considerations are outlined for a reagent to extract oxygen from organic molecules by an equivalent of dehydration.Reagents, (R3P+)2O, 2OTf-, were created for the purpose and subjected to a preliminary study.They were found to convert carboxylic acids readily and rapidly to anhydrides, esters, amides, amidines, benzimidazoles, and cyclic aryl ketones in good yields.