194093-63-5

Upstream product

• 194093-62-4 methyl 1-acetoxymethyl-5-benzyloxy-3-t-butoxycarbonyl-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate 
• 194093-61-3 3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-1-trifluoromethyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 70577-95-6 methyl 4,4,4-trifluoro-2-butynoate 
• 132628-60-5 3-acetoxymethyl-5-amino-6-benzyloxy-1-t-butoxycarbonyl-2,3-dihydro-1H-indole 

Downstream Products

• 194093-64-6 methyl 5-benzyloxy-3-t-butoxycarbonyl-1-chloromethyl-7-trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-8-carboxylate 

Relevant academic research and scientific papers

Synthesis and antitumor activity of novel cyclopropapyrroloindole(CPI) derivatives bearing methoxycarbonyl and trifluoromethyl groups

The title synthesis was achieved by employing oxidative cyclization of the enaminoester as a key step. Some of these novel 3 methoxycarbonyl-2- trifluoromethylcyclopropapyrroloindole (MCTFCPI) derivatives, dl-10c,d, (+)- 10d, and (S)-21b were found to exhibit antitumor activity against murine leukemia and murine solid tumors more prominent than that of the known CPI derivatives dl-4 and the clinical trial candidates 5 and 7.

Trifluoromethylpyrroloindolecarboxylic acid ester and process for production thereof

Trifluoromethylpyrroloindolecarboxylic acid ester derivatives, and optical isomers and pharmaceutically acceptable salts thereof are provided which are represented by the general formula (1): STR1 or the general formula (2): STR2 The compounds are antineo