194149-77-4

Basic information

• Product Name: (3R,8R,8aS)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• Synonyms: (3R,8R,8aS)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• CAS NO: 194149-77-4
• Molecular Weight: 245.321
• Mol File: 194149-77-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3R,8R,8aS)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,8R,8aS)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(194149-77-4)
• EPA Substance Registry System: (3R,8R,8aS)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine(194149-77-4)

Safety Data

• Hazardous Substances Data: 194149-77-4(Hazardous Substances Data)

Upstream product

• 194149-76-3 (3R,8S,8aR)-8-ethyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 66757-48-0 methyl 4-formylhexanoate 
• 56613-80-0 D-2-phenylglycinol 
• 104665-17-0 ethyl 4-ethyl-5-oxopentanoate 

Downstream Products

• 1273047-73-6 (3R,8R,8aS)-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-6-(phenylselenyl)-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 1273047-82-7 (3R,8R,8aS)-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-3,5,8,8atetrahydro-5H-oxazolo[3,2-a]pyridine 
• 1273048-06-8 (3R,6R,7S,8R,8aS)-6-(benzyloxycarbonyl)-8-ethyl-7-[2-(2-indolyl)-2-oxoethyl]-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 1273047-41-8 (3R,7R,8R,8aS)-8-ethyl-7-[2-(2-indolyl)-2-oxoethyl]-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 439084-93-2 (5R,6R)-5-ethyl-6-phenyl-2-piperidone 
• 908572-67-8 (5R,6R)-6-allyl-5-ethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-piperidone 
• 908572-92-9 (5R,6R)-5-ethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-6-phenyl-2-piperidone 
• 908572-98-5 (5R,6S)-5-ethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-6-vinyl-2-piperidone 
• 908572-82-7 (5R,6S)-5,6-diethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-2-piperidone 
• 908572-63-4 (5R,6R)-5-ethyl-1-[(1R)-2-hydroxy-1-phenylethyl]-6-(3-indolyl)-2-piperidone 

Relevant articles and documents

Stereoselective α-amidoalkylation of phenylglycinol-derived lactams. Synthesis of enantiopure 5,6-disubstituted 2-piperidones

The stereochemical outcome of α-amidoalkylation reactions of chiral nonracemic bicyclic lactams 2b and 2c with indole, allyltrimethylsilane, TMSCN and Grignard reagents to gain access to enantiopure 5,6-disubstituted 2-piperidones is discussed.

Alkylation of phenylglycinol-derived oxazolopiperidone lactams. Enantioselective synthesis of β-substituted piperidines

The stereochemical outcome of the alkylation of a variety of phenylglycinol-derived oxazolopiperidone lactams is studied. The influence of the configuration of the C-8a stereocenter and the effect of the substituents at the C-8 and C-8a positions on the s