66757-48-0Relevant articles and documents
Asymmetric total syntheses of rhynchophylline and isorhynchophylline
Zhang, Zhihong,Zhang, Wei,Kang, Fangyuan,Ip, Fanny C. F.,Ip, Nancy Y.,Tong, Rongbiao
, p. 11359 - 11365 (2019)
The asymmetric total syntheses of (-)-rhynchophylline and (+)-isorhynchophylline were achieved in 17 and 16 steps, respectively, from butanal and ethyl acrylate. Our synthesis features Carreira ring expansion to construct the tetracyclic spirooxindole core in high diastereoselectivity and the use of Bosch's chiral lactam for preparation of enantioenriched cyclic imine.
Synthetic noribogaine
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Page/Page column 6, (2017/05/02)
Synthetic noribogaine preferably free of ibogaine and, optionally, one or more of other naturally occurring Tabernanth iboga alkaloids, is provided.
Synthesis of Talaromycins A, B, C, and E
Baker, Raymond,Boyes, Alastairs L.,Swain, Christopher J.
, p. 1415 - 1421 (2007/10/02)
The synthesis of 2,2-diethyl-5-ethynyl-1,3-dioxane (9) is reported in an overall yield of 27percent from diethyl malonate.Addition of 5-ethyl tetrahydropyran-2-one to the lithium anion of (9) gave the hydroxy ketoacetylene (10) which was converted in four steps to the olefinic spiroacetals (19) and (20), which were obtained in a ratio of 2:1.The individual olefinic spiroacetals (19) and (20) gave access to the (+/-)-talomycins A and C, and B and E via a chlorohydration, reductive dechlorination, and deprotection sequence.
