19419-26-2Relevant academic research and scientific papers
Cholecystokinin-2/gastrin antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anti-inflammatory analgesics for the treatment of inflammatory bowel disease
Lattmann,Sattayasai,Narayanan,Ngoc,Burrell,Balaram,Palizdar,Lattmann
, p. 680 - 685 (2017)
Arylated 5-hydroxy-pyrrol-2-ones were prepared in 2 synthetic steps from mucochloric acid and optimised as CCK2-selective ligands using radiolabelled binding assays. CCK antagonism was confirmed for the ligands in isolated tissue preparations.
Lewis and Br?nsted acid catalyzed Friedel-Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides
Zhang, Ji,Blazecka, Peter G.,Curran, Timothy T.
, p. 2611 - 2615 (2007/10/03)
A catalytic, green and practical method for Friedel-Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)
