194206-03-6Relevant articles and documents
Synthesis of l -Kynurenine and Homo- l -Kynurenine via an Aza-Fries Rearrangement
Bonilla-Reyes, Edgar,Sánchez-Carrillo, Adrian,Vázquez, Alfredo
, p. 3473 - 3479 (2020)
l -Kynurenine, a non-proteinogenic amino acid, is the primary metabolite of tryptophan via the kynurenine pathway. Kynurenine is involved in a variety of biological processes occurring in the human body, notably in the central nervous system. Thus, the st
PEPTIDOMIMETIC N5-METHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE DERIVATIVES, TRIAZASPIRO[4.14]NONADECANE DERIVATIVES AND SIMILAR COMPOUNDS AS INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
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Paragraph 00455; 00679-00680, (2021/09/26)
Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sample or patient, for use in reducing the amount of noroviruses or coronaviruses in a biological sample or patient, and for use in treating norovirus and coronavirus in a patient, comprising administering to said biological sample or patient a safe and effective amount of a compound represented by formulae I or II, or a pharmaceutically acceptable salt thereof. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. page 99 to page 271; examples 1 to 3; compounds A1 to A104 and Bl to B66; tables A to E).
Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid
Matsuoka, Hiroharu,Kato, Nobuaki,Ohi, Nobuhiro,Miyamoto, Katsuhito,Mihara, Masahiko,Takeda, Yasuhisa
, p. 1146 - 1150 (2007/10/03)
The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.