142166-24-3

Upstream product

• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 142165-84-2 (S)-2-[(2,3-Dihydro-1H-indole-5-carbonyl)-amino]-4-phenylcarbamoyl-butyric acid methyl ester 
• 142165-83-1 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-phenyl-L-glutaminate 
• 194206-07-0 methyl N^δ-phenyl-L-glutaminate 
• 142165-63-7 1-carbobenzoxy-5-carboxyindoline 
• 156578-52-8 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester 
• 62-53-3 aniline 
• 72086-72-7 N-tert-butoxycarbonylglutamic acid methyl ester 
• 194206-03-6 methyl N²-(tert-butoxycarbonyl)-N⁵-phenyl-L-glutaminate 

Relevant academic research and scientific papers

Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid

The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.