194291-45-7

Upstream product

• 194291-44-6 (2R,3S,4R)-3-benzyloxy-2,4-dimethyl-5-(phenylthio)pentyl acetate 
• 882-33-7 diphenyldisulfane 
• 180188-59-4 (2S,3R,4R)-5-acetoxy-3-benzyloxy-2,4-dimethylpentanol 

Downstream Products

• 875631-03-1 (2S,8S)-3-Benzenesulfonyl-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-8-((4R,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-nonan-5-ol 
• 194291-48-0 (5R,6S,7R)-6,8-isopropylidenedioxy-5,7-dimethyl-4-phenylsulfonyl-1-octene 
• 194291-43-5 (2R,3S,4R)-1,3-isopropylidenedioxy-2,4-dimethyl-5-(phenylsulfonyl)pentane 
• 194291-47-9 (2R,3S,4R)-2,4-dimethyl-5-(phenylsulfonyl)pentane-1,3-diol 
• 194291-46-8 (2R,3S,4R)-3-benzyloxy-2,4-dimethyl-5-phenylsulfonyl-1-pentanol 

Relevant academic research and scientific papers

Synthetic study of tautomycin. Part 2: Synthesis of Ichihara's fragment based on regioselective enzymatic acetylation of complex molecule

Formal synthesis of tautomycin, which inhibits type 1 and type 2A protein phosphatases, was achieved. Spiroketal diol 21 was synthesized from alcohol 2 or 11. The regioselective enzymatic acetylation of 21 with the lipase 'Amano PS' gave monoacetate 23 in

Synthetic study of tautomycin. I. Synthesis and regioselective enzymatic acetylationof a spiroketal diol related to the C5-C16 fragment

Spiroketal diol 1 was prepared from 5, which can be obtained by enantio-selective enzymatic acetylation of meso diol 6, in 12 steps in 16.5% total yield and its regioselective protection was achieved by an enzymatic method to give 1 6 in high yield.