19430-34-3Relevant academic research and scientific papers
Efficient formation of C–S bond using heterocyclic thiones and arynes
An, Yu,Xu, Gang,Cai, Menglu,Wang, Shihui,Wang, Xiao zhong,Chen, Yingqi,Dai, Liyan
, (2020/12/23)
Phenylthio heterocyclic compounds are widely used because of their diverse biological activities and medicinal prospects. Here, a facile method was reported. An arylation of 1,3,4-oxa(thia)diazol-2-thiones reacting with arynes to build C(aryl)-S bonds in the presence of CsF had good yields and excellent selectivity. The reaction was completed in short time without using expensive reagents and catalysts. Present reaction system is an efficient procedure to process phenylthio heterocyclic compounds and reveals a sustainable method and better application prospects in future organic synthesis.
Synthesis method of aromatic thiol diazole derivatives
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Page/Page column 0039; 0040; 0055; 0056, (2020/02/10)
The invention discloses a synthesis method of aromatic thiol diazole derivatives. The method comprises the steps: using multiple thiol-containing 2,5-di-substituted oxadiazole and thiol-containing thiadiazole as raw materials, dissolves the raw materials in a certain amount of an organic solvent, adding a fluorinating agent so as to form a raw material system, closing a reaction device, performingfull replacement with N2, raising the temperature for reflux, adding a benzyne precursor with a syringe, performing a reaction for 5-6 hours, and performing post-treatment after completion of the reaction so as to obtain the aromatic thiol diazole derivatives. The reaction method has simple operation, the raw materials and reaction time are saved, and the conversion rate and selectivity of the reaction are ideal; and compared with the prior art, the synthesis method has little environmental pollution and safe operation, and is a reaction method for thiol arylation of heterocyclic compounds, and the method can be applied to arylation reactions of thiol groups on rings of oxadiazole and thiadiazole, but is not limited to preparation of aromatic thiol oxadiazole and aromatic thiol thiadiazole.
Fabrication of magnetic amino-functionalized nanoparticles for S-arylation of heterocyclic thiols
Liu, Yanhong,Zhou, Lincheng,Hui, Xinping,Dong, Zhenwen,Zhu, Hao,Shao, Yanming,Li, Yanfeng
, p. 49980 - 49985 (2014/12/10)
A series of uniformed mono-disperse magnetic nanoligands (MNLs) (CoFe2O4-NH2 (MNL A), Fe3O4@Si(CH2)3NH2 (MNL B), Fe3O4@Si(CH2)3/
Efficient copper-catalyzed C-S cross-coupling of heterocyclic thiols with aryl iodides
Niu, Liang-Feng,Cai, Yan,Liang, Chao,Hui, Xin-Ping,Xu, Peng-Fei
supporting information; experimental part, p. 2878 - 2881 (2011/05/13)
A copper-catalyzed cross-coupling of heterocyclic thiols with aryl iodides is reported. The reaction was carried out in the presence of CuI (5 mol %), 1,10-phenanthroline (10 mol %) and K2CO3 (1.3 equiv) in DMF at 120 °C. A variety o
