19432-66-7

Basic information

• Product Name: 2-Methyl-3-thiophenecarboxylic acid, ethyl ester
• Synonyms: 2-Methyl-3-thiophenecarboxylic acid, ethyl ester;Ethyl 2-Methylthiophene-3-carboxylate;2-Methyl-thiophene-3-carboxylic acid ethyl ester;Ethyl 2-methyl-3-thienylcarboxylate
• CAS NO: 19432-66-7
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.2288
• Mol File: 19432-66-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 222.023 °C at 760 mmHg
• Flash Point: 88.077 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.104mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Methyl-3-thiophenecarboxylic acid, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-thiophenecarboxylic acid, ethyl ester(19432-66-7)
• EPA Substance Registry System: 2-Methyl-3-thiophenecarboxylic acid, ethyl ester(19432-66-7)

Safety Data

• Hazardous Substances Data: 19432-66-7(Hazardous Substances Data)

Usage

General Description

2-Methyl-3-thiophenecarboxylic acid, ethyl ester, also known as ethyl 2-methyl-3-thiophenecarboxylate, is a chemical compound with the molecular formula C9H10O2S. It is a clear, colorless liquid with a fruity odor and is commonly used as a fragrance ingredient in perfumes and personal care products. It is also used as a flavoring agent in food products and as a solvent in various industrial processes. The ethyl ester form of 2-methyl-3-thiophenecarboxylic acid is considered to be relatively stable and less reactive compared to its parent acid form, making it a versatile compound for various applications in the chemical, cosmetic, and food industries.

InChI:InChI=1/C8H10O2S/c1-3-10-8(9)7-4-5-11-6(7)2/h4-5H,3H2,1-2H3

Upstream product

• 1918-79-2 2-methylthiophene-5-carboxylic acid 
• 75-03-6 ethyl iodide 
• 30319-05-2 3-bromo-2-methylthiophene 
• 541-41-3 chloroformic acid ethyl ester 
• 1918-78-1 2-methylthiophene-3-carboxylic acid 
• 554-14-3 2-Methylthiophene 
• 32595-96-3 ethyl 2-methyl-4,5-dihydrothiophene-3-carboxylate 

Relevant articles and documents

Practical preparation of ethyl 2-methylthiophene-3-carboxylate

A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.

Convenient method for the preparation of the 2-methyl thiophen-3-yl magnesium bromide lithium chloride complex and its application to the synthesis of 3-substituted 2-methylthiophenes

Lithium chloride was found to accelerate formation of the Grignard reagent from inactive 3-bromo-2-methylthiophene (1) and commercial magnesium metal. Based on this finding, a convenient and potentially scalable preparation of ethyl 2-methylthiophene-3-ca

Preparation of 2,3-Disubstituted-4,5-dihydrothiphenes and Thiophenes Using the Intramolecular Non-classical Wittig Reaction of Thiocarboxylates

2-Ethoxycarbonylcyclopropyl(triphenyl)phosphonium fluoroborate 1 reacts with alkali-methal thiolates to give 2,3-disubstituted 4,5-dihydrothiophnes 3 which can be aromatised to the corresponding thiophenes 5.