194360-39-9

Basic information

• Product Name: Phosphonic acid, [3-bromo-3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl]-, diethyl ester
• CAS NO: 194360-39-9
• Molecular Formula: C28H31BrN3O3P
• Molecular Weight: 568.45
• Mol File: 194360-39-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [3-bromo-3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [3-bromo-3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl]-, diethyl ester(194360-39-9)
• EPA Substance Registry System: Phosphonic acid, [3-bromo-3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl]-, diethyl ester(194360-39-9)

Safety Data

• Hazardous Substances Data: 194360-39-9(Hazardous Substances Data)

Upstream product

• 194359-73-4 diethyl 3-hydroxy-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate 
• 3986-95-6 diethyl (3-oxopropyl)phosphonate 
• 24385-94-2 1-trimethylsilyl-1'-diethoxy phosphono ethyne 
• 83682-72-8 γ,γ-dichloropropanol 
• 146097-19-0 diethyl 3-hydroxy-3(1-trityl-1,2,4-triazol-5-yl)propane phosphonate 
• 148062-67-3 [3-hydroxy-3-(1-trityl-1H-[1,2,4]triazol-3-yl)-prop-1-ynyl]-phosphonic acid diethyl ester 
• 31250-99-4 1-triphenylmethyl-1,2,4-triazole 
• 4851-51-8 diethyl ethynylphosphonate 

Downstream Products

• 151297-37-9 diethyl 3-azido-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate 
• 151297-36-8 diethyl 3-iodo-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate 
• 151899-99-9 [3-amino-3-(1-trityl-1H-[1,2,4]triazol-3-yl)-propyl]-phosphonic acid diethyl ester 
• 151899-90-0 diethyl 3-acetylthio-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate 
• 151296-95-6 3-aminoxy-3(1,2,4-triazol-3-yl)propane phosphonic acid 
• 151899-92-2 diethyl 3-methylthio-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate 

Relevant articles and documents

The design and synthesis of inhibitors of imidazoleglycerol phosphate dehydratase as potential herbicides

The discovery and exploration of a new class of broad-spectrum postemergent herbicides with a novel mode of action, namely the disruption of histidine biosynthesis via inhibition of imidazoleglycerol phosphate dehydratase (IGPD; E.C. 4.2.1.19), are described. Clear structural similarities between the first member, produced during an attempt to produce analogues of glyphosate, and intermediates in histidine biosynthesis were noted. Several series of targets were designed, to mimic both the enzyme substrate and a putative reaction intermediate, and synthesised. Some examples were found to be both extremely potent inhibitors of the enzyme, having K(i) values as low as 0·3 nM, and phloem-mobile herbicides with levels of weed control similar to those shown by glyphosate. Further logical progress awaits a high-resolution X-ray structure determination of an enzyme-inhibitor complex.