19446-96-9

Usage

Uses

Used in Pharmaceutical Industry:
1,1-DIOXO-1LAMBDA6-THIOCHROMAN-4-ONE is used as a pharmacological agent for its potential medicinal properties. Its unique structure and chemical characteristics make it a promising candidate for the development of new drugs, particularly in the areas of medicinal chemistry where its specific interactions and activities can be harnessed to address various health conditions.
Used in Organic Synthesis:
In the field of organic chemistry, 1,1-DIOXO-1LAMBDA6-THIOCHROMAN-4-ONE serves as a key building block. It is utilized in the synthesis of a diverse array of organic compounds, contributing to the creation of new molecules with specific applications in various industries, including but not limited to pharmaceuticals, materials science, and agrochemicals.
Used in Chemical Industry:
1,1-DIOXO-1LAMBDA6-THIOCHROMAN-4-ONE's versatility in chemical reactions and its ability to form a variety of derivatives make 1,1-DIOXO-1LAMBDA6-THIOCHROMAN-4-ONE an important molecule in the chemical industry. It is employed in the development of new chemical processes and products, enhancing the industry's capacity to innovate and meet the demands of various market sectors.

InChI:InChI=1/C9H8O3S/c10-8-5-6-13(11,12)9-4-2-1-3-7(8)9/h1-4H,5-6H2

Upstream product

• 22810-27-1 1-thiochromone 1,1-dioxide 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 503-17-3 dimethylacetylene 
• 94445-47-3 4-trimethylsilyloxy-3-thiochromene 1,1-dioxide 
• 590-18-1 (Z)-2-Butene 
• 624-64-6 trans-2-Butene 
• 109-67-1 1-penten 
• 108-94-1 cyclohexanone 
• 142-29-0 cyclopentene 
• 115-11-7 isobutene 
• 110-83-8 cyclohexene 
• 760-21-4 2-ethyl-1-butene 
• 558-37-2 tert-butylethylene 

Downstream Products

• 101318-77-8 11-benzyl-5,5-dioxo-6,11-dihydro-5H-5λ⁶-thiochromeno[4,3-b]indole-8-carboxylic acid ethyl ester 
• 106386-49-6 11-benzyl-6,11-dihydro-thiochromeno[4,3-b]indole 5,5-dioxide 
• 91126-20-4 3,5-Dioxo-4-(4-tolyl)-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-13-5 4-(2-Chlorphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-19-1 3,5-Dioxo-4-(4-nitrophenyl)-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-21-5 3,5-Dioxo-4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-17-9 3,5-Dioxo-4-(2-fluorphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-15-7 4-(3,4-Dichlorphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-16-8 4-(4-Chlor-3-nitrophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 91126-18-0 3,5-Dioxo-4-(3-fluorphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-1,1-dioxid 
• 74695-55-9 2,3-dibromothiochromone 1,1-dioxide 
• 3844-31-3 trans-thioindigo 
• 74695-57-1 2-anilino-3-bromo-4H-1-benzothiopyran-4-one 1,1-dioxide 
• 94445-52-0 3-cyclohexylidene-4-thiochromanone 1,1-dioxide 

Relevant academic research and scientific papers

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides toN-cyanosulfoximines has been developed. In total, 69 examples of sulfoxides, sulfones, andN-cyanosulfoximines have been synthesized in good to excellent yields and with high current efficiencies. The synthesis was assisted and facilitated through a supporting electrolyte-free, fully automated electrochemical protocol that highlights the advantages of flow electrolysis.

Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.

TDO2 INHIBITORS

Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Highly atom-economic, catalyst- and solvent-free oxidation of sulfides into sulfones using 30% aqueous H2O2

Highly atom-efficient oxidation of sulfides into sulfones under solvent- and catalyst-free reaction conditions using a 30% aqueous solution of H 2O2 at 75 °C is reported. A structurally diverse set of phenyl alkyl-, phenyl benzyl-, benzyl alkyl-, dialkyl-, heteroaryl alkyl- and cyclic sulfides were transformed into sulfones regardless of the aggregate state and electronic nature of the substituents. In spite of the heterogeneous reaction mixtures throughout the work, no difficulties with stirring and reaction progress were noted. In numerous cases, only 10 mol% excess of H 2O2 was used, thus contributing considerably to the high atom economy of the process. Some solid substrates required a variable excess of hydrogen peroxide; however, the reactions were performed strictly without organic solvents. The transformation was demonstrated to be amenable for scale-up with both liquid and solid sulfides. In addition, isolation and purification of the crude products can be simply done with only filtration and crystallization.

INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF

The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.

Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

A series of compounds bearing tetrahydronaphthalene, benzophenone, propiophenone, and related rigid molecular skeletons functionalized with thiosemicarbazone or unsaturated carbonyl moieties were prepared by chemical synthesis and evaluated for their ability to inhibit the enzyme cruzain. As potential treatment agents for Chagas' disease, three compounds from the group demonstrate potent inhibition of cruzain with IC50 values of 17, 24, and 80 nM, respectively.

Chemo- and diastereoselectivity in the dimethyldioxirane oxidation of 2,3-dihydro-4H-1-benzothiopyran-4-ones and 4H-1-benzothiopyran-4-ones. Unusual reactivity of 4H-1-benzothiopyran-4-one 1-oxides1

The oxidation of the 1-thiochromanones 1-3 by dimethyldioxirane (DMD) produced the corresponding sulfoxides 4-6 or sulfones 7-9; their relative amounts depended on the amount of oxidant used. A low diastereoselectivity was observed in the sulfoxidation of

Thiopyran derivatives

A thiopyran derivative represented by the following formula (I) or (I'), or the salt thereof. STR1 wherein A is S or --CH=CH--; the dotted line indicates that the bond may be either present or absent; Z and Z' are typically STR2 L is an ethylene or trimet

A mild, efficient and selective oxidation of sulfides to sulfoxides

Several titanium derivatives supported on silica have been investigated as catalysts in the sulfide→sulfoxide oxidation; the supported titanium/tartaric acid catalyst is highly suited to reactions carried out with H2O2, leading to high yields and high sulfoxide/sulfone selectivities, while small asymmetric inductions (up to 13%) are observed.