194466-58-5Relevant academic research and scientific papers
Method for treating tumors using 2-aryl-naphthyridin-4-ones
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, (2008/06/13)
The present invention provides compounds of Formula I: STR1 wherein A and R1 -R8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization
Chen, Ke,Kuo, Sheng-Chu,Hsieh, Ming-Chieh,Mauger, Anthony,Lin, Chii M.,Hamel, Ernest,Lee, Kuo-Hsiung
, p. 3049 - 3056 (2007/10/03)
As part of our continuing search for potential anticancer drug candidates in the 2-aryl-1,8-naphthyridin-4(1H)-one series, we have synthesized two series of 3'-substituted 2-phenyl-1,8-naphthyridin-4(1H)- ones and 2-naphthyl-1,8-naphthyridin-4(1H)-ones. A
