19447-06-4Relevant articles and documents
Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts
Oestreich, Martin,Seliger, Jan
supporting information, p. 247 - 251 (2020/10/29)
A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.
PROCESS FOR PREPARING SUBSTITUTED 2-ARYLETHANOLS
-
Paragraph 0072, (2019/02/05)
The invention relates to a process for preparing substituted 2-arylethanols of the formula (I) by reacting Grignard compounds of the formula (II) in the presence of a copper compound with ethylene oxide. Moreover, the invention relates to novel substituted 2-arylethanols of the formula (I).
Half-sandwich ruthenium-based versatile catalyst for both alcohol oxidation and catalytic hydrogenation of carbonyl compounds in aqueous media
Qiao, Xin-Chao,Qiu, Dan-Chen,Lin, Nan,Zhu, Jing-Wei,Deng, Wei,Yao, Zi-Jian
, (2019/03/17)
A series of half-sandwich ruthenium-based catalysts for both alcohol oxidation and carbonyl compounds hydrogenation have been synthesized through metal-induced C–H bond activation based on benzothiazole ligands. The neutral ruthenium complexes 1–4 were fully characterized by UV–vis, NMR, IR, and elemental analysis. Molecular structures of complexes 1 and 3 were further confirmed by X-ray diffraction analysis. All complexes exhibited high activity for the catalytic oxidation of a variety of alcohols with tBuOOH as oxidants to give carbonyl compounds with high yields in water. Moreover, these half-sandwich complexes also showed high efficiency for the catalytic hydrogenation of carbonyl compounds in a methanol–water mixture. The catalyst could be reused for at least five cycles without any loss of activity. The catalytic system also worked well for various kinds of substrates with either electron-donating or electron-withdrawing groups.