194472-61-2Relevant articles and documents
Enantioselective Allylation of Aldehydes with an Optically Active Allylsilane
Hayashi, Tamio,Konishi, Mitsuo,Kumada, Makoto
, p. 281 - 282 (1983)
Reaction of aldehydes with an optically active allylsilane, (R)-3-phenyl-3-(trimethylsilyl)propene, in the presence of titanium chloride has been found to proceed with high enantioselectivity to produce optically active homoallylic alcohols of up to 91per
VINYLOGOUS PHENETHYLAMINES AS NEUROTRANSMITTER RELEASERS
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Paragraph 00127; 00128, (2017/12/02)
The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phe
The biogenic amine transporter activity of vinylogous amphetamine analogs
Decker, Ann M.,Partilla, John S.,Baumann, Michael H.,Rothman, Richard B.,Blough, Bruce E.
supporting information, p. 1657 - 1663 (2016/08/24)
A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S-6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability.
Synthesis of enantiomerically pure monosubstituted 1,2λ5-oxaphospholanes. Synthesis of homoallylic alcohols
Okuma, Kentaro,Tanaka, Yu-Ichiro,Hirabayashi, Syun-Ichi,Shioji, Kosei,Matsuyama, Haruo
, p. 1385 - 1390 (2007/10/03)
Enantiomerically pure 5-monosubstituted 1,2λ5-oxaphospholanes were synthesized by the reaction of sodium hydride with enantiomerically pure 3-hydroxyalkyl-triphenylphosphonium salts. The reaction of 1,2λ5-oxaphospholanes with aldehyd
