194599-72-9Relevant articles and documents
Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors
Baker, Christopher T.,Salituro, Francesco G.,Court, John J.,Deininger, David D.,Kim, Eunice E.,Li, Biquin,Novak, Perry M.,Rao, Bhisetti G.,Pazhanisamy,Schairer, Wayne C.,Tung, Roger D.
, p. 3631 - 3636 (1998)
A combination of structure-based design and both solution, and solid- phase synthesis were utilized to derive a potent (nM) series of HIV-1 protease inhibitors bearing a structurally novel backbone. Detailed structural analysis of several inhibitors prepared in this series has suggested that rigidification of the P1/P2 region of this class of molecules may result in compounds with improved potency.
