194608-89-4

Upstream product

• 91361-78-3 3-chloro-4-dimethylcarbamoylthio-phenylacetic acid methyl ester 
• 709028-29-5 (3-Chloro-4-{3-[3-hydroxy-2-propyl-4-(2,2,2-trifluoro-acetyl)-phenoxy]-propylsulfanyl}-phenyl)-acetic acid methyl ester 
• 194792-52-4 methyl 3-chloro-4-(3-bromopropylthio)-phenylacetate 
• 91373-91-0 (3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester 
• 65239-69-2 2,4-dihydroxy-3-propyl-1',1',1'-trifluoroacetophenone 
• 57017-95-5 methyl 3-chloro-4-hydroxyphenylacetate 
• 315-44-6 2,4-dihydroxy-1’,1’,1’-trifluoroacetophenone 
• 591749-04-1 5-bromo-6-(3-bromopropyloxy)-7-propyl-3-trifluoromethyl-benzisoxazole 
• 591749-03-0 5-bromo-6-hydroxy-7-propyl-3-trifluoromethyl-benzisoxazole 
• 194608-88-3 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole 
• 91361-79-4 3-chloro-4-sulphanyl-phenylacetic acid methyl ester 
• 194608-95-2 6-(3-bromopropyloxy)-7-propyl-3-trifluoromethyl-benzisoxazole 
• 709028-30-8 {3-Chloro-4-[3-(3-hydroxy-2-propyl-4-{2,2,2-trifluoro-1-[(Z)-hydroxyimino]-ethyl}-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 
• 709028-25-1 1-(3-allyl-2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

Synthesis of tritium labelled L783483 - A PPARδ ligand

The potent peroxisome proliferator-activated receptor (PPAR) δ ligand L783483 (3-chloro-4-(3-(7-propyl-3-trifluoromethyl-benzisoxazol-6-oxy) pro-pylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5-brom

Phenylacetic acid derivatives as hPPAR agonists

Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. F