19461-34-8Relevant articles and documents
Lipase-mediated kinetic separation of a diastereomeric mixture of 4-tert-butylcyclohexanemethanol
Hiroya,Hasegawa,Watanabe,Ogasawara
, p. 379 - 381 (2007/10/02)
Diastereomerically pure trans- and cis-4-tert-butylcyclohexanemethanols have been obtained by kinetic acylation of the diastereomeric alcohol in an organic medium and by kinetic deacylation of the diastereomeric acetate in an aqueous medium both in the presence of the same lipase (lipase PS, Pseudomonas sp., Amano). The reactions take place preferentially with the trans-isomers both in organic and aqueous media to give the trans-acetate with recovery of the cis-alcohol on acylation in an organic medium,and the trans-alcohol with recovery of the cis-acetate on deacylation in an aqueous medium.
127. Conformationally Controlled Odor Perception in 'Steroid-type' Scent Molecules
Ohloff, Guenther,Giersch, Wolfgang,Thommen, Walter,Willhalm, Bruno
, p. 1343 - 1354 (2007/10/02)
A series of compounds possessing a 'steroid-type' scent and related to 4-(4'-t-butylcyclohexyl)-4-methyl-2-pentanones (1 and 2) have been synthesized.The odor of these compounds has been found to be dependent on their conformation; only when the molecule can assume a steroid-like shape there is an interaction with the odor chemoreceptor.