19464-43-8Relevant articles and documents
Ferrocenyl-Triphenyltin Complexes as Lysosome-Targeted Imaging and Anticancer Agents
Li, Juanjuan,Liu, Xicheng,Zhang, Haifeng,Ge, Xingxing,Tang, Yanhua,Xu, Zhishan,Tian, Laijin,Yuan, Xiangai,Mao, Xudong,Liu, Zhe
, p. 1710 - 1718 (2019)
In this paper, two ferrocenyl-triphenyltin complexes were synthesized and characterized. Complex 2 is constructed as new multifunctional therapeutic platform for lysosome-targeted imaging and displayed much higher cytotoxicity than its analogue 1 by the introduction of a methyl group instead of a hydrogen atom in acylhydrazone. The cyclic voltammograms and reaction with GSH (glutathione) further confirmed that complex 1 has a reversible redox peak and can react with GSH, which indicate that complex 1 might lose its anticancer effect by undergoing reaction with GSH once it enters the cancer cell. Complex 2 could effectively catalyze the oxidation of NADH (the reduced form of nicotinamide adenine dinucleotide) to NAD+ and induce the production of reactive oxygen species (ROS), lead to caspase-dependent apoptosis through damaged mitochondria, simultaneously, accounting for the mitochondrial vacuolization and karyorrhexis. The caspase-3 activation and cytoplasmic vacuolation karyorrhexis induced by complex 2 revealed that the A549 cell lines might undergo cell death primarily mediated by apoptosis and oncosis; however, 1 cannot reproduce this effect. Taken together, these results indicated that complex 2 has more potential for evolution as a new bioimaging and anticancer agent.
Free radical hydrostannylation of unactivated alkenes with chiral trialkylstannanes
Kavanagh, Yvonne,Ford, Leigh,Schiesser, Carl H.
, p. 4387 - 4392 (2011/10/10)
Free radical hydrostannylation of olefins with differing steric and electronic demands have been carried out using the chiral, nonracemic stannanes (1R,2S,5R)-menthyldiphenyltin hydride (7), bis[(1R,2S,5R)-menthyl]phenyltin hydride (8), and tris[(1R,2S,5R
Homogeneous Sonochemistry in Radical Chain Reactions. Sonochemical Hydrostannation and Tin Hydride Reduction
Nakamura, Eiichi,Machii, Daisuke,Inubushi, Tsuyoshi
, p. 6849 - 6850 (2007/10/02)
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