76-87-9Relevant articles and documents
Structural and in vitro biological studies of organotin(iv) precursors; Selective inhibitory activity against human breast cancer cells, positive to estrogen receptors
Balas, Vasilis I.,Banti, Christina N.,Kourkoumelis, Nikolaos,Hadjikakou, Sotiris K.,Geromichalos, George D.,Sahpazidou, Despina,Male, Louise,Hursthouse, Mike B.,Bednarz, Barbara,Kubicki, MacIej,Charalabopoulos, Konstantinos,Hadjiliadis, Nick
, p. 1625 - 1637 (2012)
Crystals of Ph3SnCl (1) were grown from a methanol/acetonitrile solution. Compounds [Ph3SnOH]n (2) and [(Ph 2Sn)4Cl2O2(OH)2] (3) were crystallized from diethyl ether/methanol/acetonitrile and hot acetone/water solutions respectively, of the white precipitation, formed by adding KOH to solutions of 1 and [Ph2SnCl2] in 1:1 and 1:2 molar ratios respectively. Complex 1 was characterized by X-ray crystallography. X-ray structure determination of compounds 2 and 3 confirmed the previously reported identities. The molecular structure of 1, reported here, is a new polymorphic form of the known one for Ph3SnCl. Four independent [Ph 3SnCl] molecules constitute the crystal structure of 1. The moieties are packed in two pairs in a tail-to-tail arrangement. Complexes 1-3 were evaluated for their in vitro cytotoxic activity (cell viability) against human cancer cell lines: HeLa (human cervical), MCF-7 (breast, estrogen receptor (ER) positive), MDA-MB-231 (breast, ER negative), A549 (lung), Caki-1 (kidney carcinoma), 786-O (renal adenocarcinoma), K1 (thyroid carcinoma), and the normal human lung cell line MRC-5 (normal human fetal lung fibroblast cells) versus, the normal immortalized human mammary gland epithelial cell line MTSV17 with a sulforhodamine B (SRB) assay. The results show potent cytotoxic activity of the complexes against all cell lines used, which was superior to that of cisplatin (CDDP). Compounds 1-3 showed higher activity against breast cancer cells MCF-7 (ER positive) than against of MDA-MB-231 (ER negative). These findings prompted us to search for possible interaction of these complexes with other cellular elements of fundamental importance in cell proliferation. The influence of these complexes 1-3 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX), as well as their binding affinity towards calf thymus-DNA, were kinetically and theoretically studied.
Synthesis, structural characterization, Hirshfeld surface analysis and in vitro-antimicrobial activities of triphenyltin (IV) compounds of azo-carboxylates derived from 2- or 4-amino benzoic acids and naphthalen-1 or 2-ol
Debnath, Paresh,Debnath, Pratima,Maniukiewicz, Waldemar,Sharma, Swastika,Sieroń, Les?aw,Singh, Keisham Surjit,Singh, S. Sureshkumar
, (2021)
Synthesis of three new triphenyltin(IV) compounds 1–3 were reported by the reaction of azo-carboxylic acid ligands viz.2/4-(2-hydroxynaphthylazo)-benzoic acids [compounds 1 and 2] or 2-(4-hydroxynaphthylazo)-benzoic acid [compound 3] with triphenyltin(IV)
The synthesis, characterization and comparative anticorrosion study of some organotin(IV) 4-chlorobenzoates
Kurniasih, Hastin,Nurissalam, Muhamad,Iswantoro, Bambang,Afriyani, Hapin,Qudus, Hardoko Insan,Hadi, Sutopo
, p. 2377 - 2383 (2016/02/27)
The synthesis of 3 compounds of a series of dibutyl(IV) di-4-chlorobenzoate, diphenyl(IV) di-4-chlorobenzoate and triphenyltin(IV) 4-chlorobenzoate have successfully been performed by reacting the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with 4-chlorobenzoic acid. All compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The anticorrosion activity of these compounds were tested on Hot Roller Plate (HRP) mild steel in DMSO-HCl solution using potentiodynamic method. The results revealed that the triphenyltin(IV) 4-chlorobenzoate clearly showed the strongest inhibitor activity compared to the other derivatives, while diphenyltin(IV) compounds were better than that of dibutyltin(IV) analogous. The results reported here indicated that the optimal activity were depended on the ligand attached to the metal centre and might also be related to the number of carbon atoms present in the organotin(IV) used.
