194652-85-2

Upstream product

• 139887-99-3 3'-O-(tert-butyldimethylsilyl)-4'-(hydroxymethyl)-thymidine 
• 194652-84-1 1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 194652-93-2 N-[(Aminocarbonyl)methyl]-3',5'-di-O-benzoylthymidine-4'-carboxamide 
• 194652-97-6 N-(2-Hydroxymethyl)-3',5'-di-O-benzoylthymidine-4'-carboxamide 
• 194652-95-4 N,N-Dimethyl-3',5'-di-O-benzoylthymidine-4'-carboxamide 
• 194652-86-3 (2R,3S,5R)-3-Benzoyloxy-2-benzoyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid 

Relevant academic research and scientific papers

Preparation of thymidine-4′-C-carboxylic acid and its derivatives

3′,5′-Di-O-benzoyl-4′-C-hydroxymethylthymidine (3) was prepared in four steps from 3′-O-(tert-butyldimethylsilyl)-4′-C-hydroxymethylthymidine (1). Oxidation of 3 with pyridinium dichromate afforded 3′,5′-di-O-benzoylthymidine-4′-C-carboxylic acid (4) whic