Preparation of thymidine-4′-C-carboxylic acid and its derivatives

Article abstract of DOI:10.1135/cccc19971128

3′,5′-Di-O-benzoyl-4′-C-hydroxymethylthymidine (3) was prepared in four steps from 3′-O-(tert-butyldimethylsilyl)-4′-C-hydroxymethylthymidine (1). Oxidation of 3 with pyridinium dichromate afforded 3′,5′-di-O-benzoylthymidine-4′-C-carboxylic acid (4) whic