194664-41-0

Upstream product

• 192320-28-8 C₂₇H₂₇N₃O₆S 
• 194664-25-0 C₂₀H₂₁N₃O₆S 
• 194664-23-8 C₁₅H₁₃N₃O₄S 
• 5331-43-1 N-benzyloxycarbonyl-hydrazine 
• 57699-97-5 N^α-benzyl-N^α-(benzyloxycarbonyl)-N^β-(tert-butyloxycarbonyl)hydrazine 
• 194664-32-9 C₂₁H₂₆N₂O₄ 

Downstream Products

• 194664-45-4 N-Benzyl-N'-(4-fluoro-benzoyl)-N'-methyl-hydrazinecarboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of hydrazines with aromatic substituents using triarylbismuth reagents

Smooth monoarylation of two triprotected hydrazine reagents under mild conditions has been accomplished using triarylbismuthanes in the presence of copper acetate and amine to give products 3 and 6 in excellent yield. Arylation on N2 after selective deprotection of derivatives with alkyl or aryl substituents on N1, resulting in compounds 8 and 9, is also demonstrated. Furthermore, other products derived from these reagents with free N-alkyl and N-aryl functions undergo the same reaction to give substances such as 10 and 11. As a result, the scope of the original hydrazine reagents has been further extended. A few reference compounds have also been prepared directly from phenylhydrazine.

Stepwise synthesis of tetrasubstituted hydrazines

A new triprotected hydrazine reagent has been made and applied in alkylation/acylation reactions for stepwise synthesis of tetrasubstituted derivatives in high purity and yield.