57699-97-5

Upstream product

• 501-53-1 benzyl chloroformate 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 
• 192320-27-7 1-benzyl-1-benzyloxycarbonyl-2-tert-butyloxycarbonyl-2-(4-toluenesulfonyl)-hydrazine 
• 100-52-7 benzaldehyde 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 194664-25-0 C₂₀H₂₁N₃O₆S 
• 194664-23-8 C₁₅H₁₃N₃O₄S 
• 200813-53-2 1-tert-butoxycarbonyl-1-tosyl-2-benzyloxycarbonylhydrazine 
• 200813-52-1 benzyl 2-tosylhydrazine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 287729-07-1 N-benzyl-N-benzyloxycarbonylaminophthalimide 
• 287728-91-0 N-benzyloxycarbonylaminophthalimide 
• 426840-26-8 N^α-benzyl-N^α-(benzyloxycarbonyl)-N^β,N^β-bis(tert-butyloxycarbonyl)hydrazine 

Downstream Products

• 5501-26-8 1-benzyl-1-benzyloxycarbonylhydrazine 
• 194664-32-9 C₂₁H₂₆N₂O₄ 
• 194664-33-0 C₂₄H₃₀N₂O₆ 
• 194664-41-0 2-Benzyl-2-benzyloxycarbonyl-1-methylhydrazine 
• 194664-42-1 (N'-Benzyl-N'-benzyloxycarbonyl-hydrazino)-acetic acid ethyl ester 
• 194664-45-4 N-Benzyl-N'-(4-fluoro-benzoyl)-N'-methyl-hydrazinecarboxylic acid benzyl ester 

Relevant academic research and scientific papers

Preparation of Multiply Protected Alkylhydrazine Derivatives by Mitsunobu and PTC Approaches

Alkylation reactions of hydrazine derivatives by Mitsunobu or PTC approaches are described. It has been shown that aminophthalimide derivatives are better acidic partners than their aminoimidodicarbonate (NBoc2) analogues, the presence of the phthaloyl group increasing the acidity of the sole proton and concomitantly reducing steric hindrance. Moreover, N-aminophthalimide derivatives can be efficiently converted into the corresponding N-amino-imidodicarbonates by a three-stage, one-flask procedure under very mild conditions. These procedures can also be efficiently used for the preparation of orthogonally Nα,Nβ -diprotected α-hydrazino esters. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

Very efficient one-pot conversion of N-aminophthalimide derivatives into the corresponding N-amino-di-tert-butyl imidodicarbonates

The phthaloyl group can be efficiently converted in very mild conditions into bis-tert-butyloxycarbonyl group using MeNH2, then Boc2O/DMAP, in a one-flask protocol.

Mild, efficient cleavage of arenesulfonamides by magnesium reduction

The cleavage of arenesulfonamides via N-arenesulfonylcarbamates is achieved within a few minutes under ultrasonic conditions by reaction with magnesium in anhydrous methanol.

A practical reagent for the synthesis of substituted hydrazines

A practical, inexpensive triprotected hydrazine reagent, 2-benzyloxycarbonyl-1 -tert-butoxycarbonyl-1- (4-methylphenylsulfonyl)-hydrazine, 1-Boc-1-Tos-2-Z-hydrazine (2), has been prepared on a 100 pnmol scale and examined with respect to application in st

Stepwise synthesis of tetrasubstituted hydrazines

A new triprotected hydrazine reagent has been made and applied in alkylation/acylation reactions for stepwise synthesis of tetrasubstituted derivatives in high purity and yield.