1947-39-3Relevant articles and documents
Efficient chemo-enzymatic synthesis of endomorphin-1 using organic solvent stable proteases to green the synthesis of the peptide
Sun, Honglin,He, Bingfang,Xu, Jiaxing,Wu, Bin,Ouyang, Pingkai
experimental part, p. 1680 - 1685 (2011/08/07)
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1), an effective analgesic, was efficiently synthesized by a combination of enzymatic and chemical methods. Peptide Boc-Trp-Phe-NH2 was synthesized with a high yield of 97.1% by the solvent-stab
SYNTHESIS OF THE CARBOXY-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ (CCK-8) BASED ON INCORPORATION OF O4-SULFOTYROSINE BY ENZYMATICALLY CATALYZED FORMATION OF PEPTIDE BONDS
Cerovsky, Vaclav,Hlavacek, Jan,Slaninova, Jirina,Jost, Karel
, p. 1086 - 1093 (2007/10/02)
Papain-catalyzed condensation of sodium salt of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine (fragment 1-2) with methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide (fragment 3-8) has been elaborated.Deprotectio