194713-60-5Relevant academic research and scientific papers
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential
Madhavan, Gurram R.,Chakrabarti, Ranjan,Anantha Reddy,Rajesh,Balraju,Bheema Rao,Rajagopalan,Iqbal, Javed
, p. 584 - 591 (2006)
2,4-Thiazolidinedione derivatives of 1,3-benzoxazinone were synthesized and evaluated for their PPAR-α and -γ dual activation. DRF-2519, a compound obtained through SAR of TZD derivatives of benzoxazinone, has shown potent dual PPAR activation. In ob/ob mice, it showed better efficacy than the comparator molecules. In fat fed rat model, it showed significant improvement in lipid parameters, which was better than fibrates.
Benzoazine derivative or salt thereof and pharmaceutical compostion comprising the same
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, (2008/06/13)
A benzoazine derivative represented by the following formula (1), STR1 wherein R1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group,
