194721-53-4

Upstream product

• 35378-82-6 2,5,8-undecatriyne-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 97526-03-9 2-undeca-2,5,8-triynyloxy-tetrahydro-pyran 
• 40924-58-1 tetrahydro-2-(2,5-hexadiynyloxy)-2H-pyrane 
• 92666-05-2 toluene-4-sulfonic acid pent-2-ynyl ester 
• 6261-22-9 pent-2-yn-1-ol 
• 16400-32-1 1-bromo-pent-2-yne 

Downstream Products

• 194721-55-6 1-tosyloxy-2,5,8,11-tetradecatetrayne 
• 5871-10-3 2,5,8,11-tetradecatetrayne-1-ol 
• 10417-94-4 all cis-5,8,11,14,17-eicosapentaenoic acid 

Relevant academic research and scientific papers

METHOD FOR THE SYNTHESIS OF DHA

A method for preparing docosahexaenoic acid (DHA). The method comprises coupling a compound represented by Formula I with a compound represented by Formula II followed by partial hydrogenation to obtain a compound represented by Formula III. The compound represented by Formula III acts as a DHA precursor and thus can be hydrolysed to obtain DHA. Novel starting materials represented by Formula I and Formula II, and synthetic routes for preparing the same are also provided.

A Novel Synthesis of (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic Acid and Its Acetylenic Precursor

A novel procedure of synthesis of (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic (timnodonic) acid and its acetylenic precursor, 5,8,11,14,17-eicosapentaynoic acid was developed.It uses polyacetylene strategy and a known reaction of cross-coupling between propargyl units and ω-acetylenes in the presence of copper(I) and sodium iodides and involves the in situ formation of organocopper compounds and propargyl iodides. - Key words: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid; 5,8,11,14,17-eicosapentaynoic acid; polyacetylenic alcohols; cross-coupling