19473-96-2Relevant articles and documents
Histone deacetylase inhibitor as well as preparation and application thereof
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Paragraph 0044-0045, (2021/04/28)
The invention relates to a histone deacetylase inhibitor and preparation and an application thereof, in particular to a novel histone deacetylase inhibitor based on a beta-elemene structure and a preparation method thereof, and further relates to an intermediate for synthesizing the histone deacetylase inhibitor and a preparation method thereof. The invention also relates to an application of the histone deacetylase inhibitor in preparation of antitumor drugs, and belongs to the technical field of chemical synthesis of drugs. The zinc ion combined compound and the salt or solvate thereof are shown as a general formula (I) or (II), wherein R, X, n and i are described in the claims and the specification.
Acrylamide benzoazepine derivatives as GSK-3beta inhibitors and applications thereof
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Paragraph 0051-0054, (2020/11/26)
The invention belongs to the technical field of medicinal chemistry, and discloses acrylamide benzoazepine derivatives serving as glycogen synthase kinase-3beta (GSK-3beta) inhibitors and applicationsof the acrylamide benzoaza derivatives. The derivatives are compounds shown as a formula (I) or pharmaceutically acceptable salts thereof. The compounds have good inhibitory activity on GSK-3beta andcan be used as selective inhibitors for preventing and treating GSK-3beta-related diseases, and the GSK-3beta-related diseases include cancer, neurodegenerative diseases and diabetes.
Preparation method of pemetrexed acid
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Paragraph 0043; 0044, (2019/05/16)
Belonging to the technical field of organic compound synthesis, the invention in particular relates to a preparation method of pemetrexed acid. The method is characterized by utilizing methyl p-formylbenzoate and malonic acid as the starting materials to synthesize the target product. Compared with the methods for synthesis of the compound reported in previous literatures, the method provided by the invention has the advantages of easily available raw materials, low price and no pollution, greatly reduces the production cost, and is suitable for large-scale industrial production. The method isa brand new synthetic route for the compound.