158475-38-8

Upstream product

• 187737-37-7 propene 
• 20883-45-8 4-methoxycarbonyl-phenylmercury ⁽¹⁺⁾; chloride 
• 1571-08-0 methyl 4-formylbenzoate 
• 1754-88-7 ethylenetriphenylphosphorane 
• 117390-07-5 (E)-4-(methoxycarbonyl)cinnamic acid 
• 110-05-4 di-tert-butyl peroxide 
• 19473-96-2 4-(2-carboxyvinyl)benzoic acid methyl ester 
• 590-14-7 1-bromo-1-propene 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 67-56-1 methanol 
• 115665-91-3 (E)-4-(2-methanesulfonyl-vinyl)-benzoic acid methyl ester 

Downstream Products

• 117389-63-6 (E)-methyl 4-(3-bromoprop-1-en-1-yl)benzoate 

Relevant academic research and scientific papers

Direct Photoexcitation of Xanthate Anions for Deoxygenative Alkenylation of Alcohols

In this report, we identify xanthate salts as a unique class of visible-light-excitable alkyl radical precursors that act simultaneously as strong photoreductants and alkyl radical sources. Upon direct photoexcitation of xanthate anions, efficient deoxygenative alkenylation and alkylation of a wide range of primary, secondary, and tertiary alcohols have been achieved via a one-pot protocol, avoiding any photocatalysts. This method exhibits a broad substrate scope and good functional group tolerance, enabling late-stage functionalization of complex molecules.

Enantio- and Regioselective NiH-Catalyzed Reductive Hydroarylation of Vinylarenes with Aryl Iodides

A highly enantio- and regioselective hydroarylation process of vinylarenes with aryl halides has been developed using a NiH catalyst and a new chiral bis imidazoline ligand. A broad range of structurally diverse, enantioenriched 1,1-diarylalkanes, a structure found in a number of biologically active molecules, have been obtained with excellent yields and enantioselectivities under extremely mild conditions.

A Stereoconvergent Cyclopropanation Reaction of Styrenes

The first stereoconvergent cyclopropanation reaction by means of photoredox catalysis using diiodomethane as the methylene source is described. This transformation exhibits broad functional group tolerance and it is characterized by an excellent stereocontrol en route to trans-cyclopropanes regardless of whether E- or Z-styrene substrates were utilized.

Preparation of Vinyl Arenes by Nickel-Catalyzed Reductive Coupling of Aryl Halides with Vinyl Bromides

This work emphasizes the synthesis of substituted vinyl arenes by reductive coupling of aryl halides with vinyl bromides under mild and easy-to-operate nickel-catalyzed reaction conditions. A broad range of aryl halides, including heteroaromatics, and vinyl bromides were employed to yielding products in moderate to excellent yields with high functional-group tolerance. The nickel-catalytic system displays good chemoselectivity between the two C(sp2)-halide coupling partners, thus demonstrating a mechanistic pathway distinct from other stepwise protocols.

Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions

It is the first time to find that iron-catalyzed decarboxylative methylation of α,β-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-t

Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions

It is the first time to find that iron-catalyzed decarboxylative methylation of α,β-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-t

Generation of an Ugi library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors

The four-component Ugi reaction was utilized to prepare a library of dipeptidic compounds in order to explore the binding requirements of the key cell cycle phosphatase, Cdc25. Several phosphate surrogates were incorporated into the Ugi product to mimic either the mono- or bis-phosphorylated substrate.