194737-53-6

Upstream product

• 154631-82-0 (2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 

Downstream Products

• 202473-18-5 (2S,3S,4R)-3-hydroxy-4-aminoproline 
• 194737-67-2 tert-butyl (2R,3S,4R)-4-tert-butoxycarboxamido-2-tert-butyldiphenylsilyloxymethyl-3-mesyloxy-pyrrolidine-1-carboxylate 
• 194737-66-1 tert-butyl (2R,3S,4R)-4-tert-butoxycarboxamido-2-tert-butyldiphenylsilyloxymethyl-3-hydroxy-pyrrolidine-1-carboxylate 
• 194737-65-0 tert-butyl (2R,3R,4R)-4-azido-2-tert-butyldiphenylsilyloxymethyl-3-hydroxy-pyrrolidine-1-carboxylate 
• 194737-63-8 tert-butyl (2R,3R,4S)-2-tert-butyldiphenylsilyloxymethyl-3,4-epoxypyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of 2-amido, 2-amino, and 2-azido derivatives of the nitrogen analogue of the naturally occurring glycosidase inhibitor salacinol and their inhibitory activities against O-GlcNAcase and NagZ enzymes

Seven 2-substituted derivatives of the nitrogen analogue of salacinol, a naturally occurring glycosidase inhibitor, were synthesized for structure-activity studies with hexosaminidase enzymes. The target zwitterionic compounds were synthesized by means of

Synthesis of trans-epoxy-L-proline and cis-aziridino-L-proline from S-pyroglutamic acid. Regio- and diastereoselective ring opening of its derivatives

The pyroglutamic acid derivative 4 was converted through several steps into 2S,3R,4S-epoxyproline 8. Key steps of the reaction sequence were the stereoselective epoxidation of 4 to 5 and the chemoselective reduction of the amide group of 5 with concomitan