194737-65-0

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 194737-57-0 tert-butyl (2R,3R,4R)-4-azido-3-hydroxy-2-hydroxymethylpyrrolidine-1-carboxylate 
• 194737-55-8 tert-butyl (2R,3R,4S)-3,4-epoxy-2-hydroxymethylpyrrolidine-1-carboxylate 
• 194737-53-6 N-benzyl-2,3-epoxy-1,4-imino-1,2,3,4-tetradeoxy-D-ribitol 
• 154631-82-0 (2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 

Downstream Products

• 194737-66-1 tert-butyl (2R,3S,4R)-4-tert-butoxycarboxamido-2-tert-butyldiphenylsilyloxymethyl-3-hydroxy-pyrrolidine-1-carboxylate 
• 194737-67-2 tert-butyl (2R,3S,4R)-4-tert-butoxycarboxamido-2-tert-butyldiphenylsilyloxymethyl-3-mesyloxy-pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of trans-epoxy-L-proline and cis-aziridino-L-proline from S-pyroglutamic acid. Regio- and diastereoselective ring opening of its derivatives

The pyroglutamic acid derivative 4 was converted through several steps into 2S,3R,4S-epoxyproline 8. Key steps of the reaction sequence were the stereoselective epoxidation of 4 to 5 and the chemoselective reduction of the amide group of 5 with concomitan