194804-80-3 Usage
Description
2,4-Difluoro-3-hydroxybenzoic acid methyl ester is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 4th positions of the benzene ring, a hydroxyl group at the 3rd position, and a methyl ester functional group. This molecule is known for its potential applications in the pharmaceutical industry due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
2,4-Difluoro-3-hydroxybenzoic acid methyl ester is used as a reactant for the preparation of fluoroquinolone drugs, specifically Garenoxacin. This application is based on its ability to serve as a key intermediate in the synthesis of the drug, which is a potent antibiotic used to treat various bacterial infections. The presence of fluorine atoms in the molecule enhances the drug's activity and pharmacokinetic properties, making it more effective against a wide range of bacterial pathogens.
Check Digit Verification of cas no
The CAS Registry Mumber 194804-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,8,0 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 194804-80:
(8*1)+(7*9)+(6*4)+(5*8)+(4*0)+(3*4)+(2*8)+(1*0)=163
163 % 10 = 3
So 194804-80-3 is a valid CAS Registry Number.
194804-80-3Relevant articles and documents
2-Chloro-2,2-difluoroacetophenone: A non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives
Zhang, Laijun,Zheng, Ji,Hu, Jinbo
, p. 9845 - 9848 (2007/10/03)
A novel and non-ODS-based (ODS = ozone-depleting substance) preparation of 2-chloro-2,2-difluoroacetophenone (1) was achieved in high yield by using 2,2,2-trifluoroacetophenone as the starting material. Compound 1 was found to act as a good difluorocarbene reagent, which readily reacts with a variety of structurally diverse phenol derivatives 4 in the presence of potassium hydroxide or potassium carbonate to produce aryl difluoromethyl ethers 5 in good yields. This new and easy-to-handle synthetic methodology offers an environmentally friendly alternative to other Freon- or Halon-based difluoromethylating approaches.