194808-59-8

Upstream product

• 14209-32-6 3-(4-[(2-cyanoethyl)amino]butylamino)propanenitrile 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 110-60-1 1,4-diaminobutane 
• 107-13-1 acrylonitrile 

Downstream Products

• 177213-61-5 di-tert-butyl butane-1,4-diylbis((3-aminopropyl)carbamate) 
• 114459-62-0 tri-Boc-spermine 
• 103493-12-5 N¹,N⁸-bis(benzyloxycarbonyl)spermine 
• 221226-22-8 (3-benzyloxycarbonylamino-propyl)-{4-[(3-benzyloxycarbonylamino-propyl)-tert-butoxycarbonyl-amino]-butyl}-carbamic acid tert-butyl ester 
• 1297523-34-2 N⁽¹⁾-p-nitrobenzoyl-N⁽⁴⁾,N⁽⁹⁾,N⁽¹²⁾-tri-(tert-butyloxycarbonyl)-1,12-diamino-4,9-diazadodecane 
• 1297523-37-5 N⁽¹⁾-(p-aminobenzoyl)-N⁽⁴⁾,N⁽⁹⁾,N⁽¹²⁾-tri-(tert-butyloxycarbonyl)-1,12-diamino-4,9-diazadodecane 
• 1372551-51-3 N⁽¹⁾,N⁽⁴⁾-di(tert-butyloxycarbonyl)-N⁽¹⁾-2-cyanoethyl-N⁽⁴⁾-3-aminopropyl-1,4-butanediamine 
• 1643593-20-7 C₄₀H₅₄Br₄N₄O₈ 
• 1643593-19-4 C₄₀H₅₂Br₆N₄O₈ 
• 1643593-18-3 C₄₀H₅₂Br₆N₄O₈ 
• 1643593-17-2 C₄₀H₅₂Br₆N₄O₈ 

Relevant academic research and scientific papers

Syntheses of a library of molecules on the marine natural product ianthelliformisamines platform and their biological evaluation

Ianthelliformisamines A-C are a novel class of bromotyrosine-derived antibacterial agents isolated recently from the marine sponge Suberea ianthelliformis. We have synthesized ianthelliformisamines A-C straightforwardly by the condensation of (E)-3-(3,5-dibromo-4-methoxyphenyl)acrylic acid and the corresponding Boc-protected polyamine followed by Boc-deprotection with TFA. Further, using this reaction protocol, a library of their analogues (39 analogues) has been synthesized by employing 3-phenylacrylic acid derivatives and Boc-protected polyamine chains through various combinations of these two fragments differing in phenyl ring substitution, double bond geometry or chain length of the central spacer of the polyamine chain (shown in red color). All the synthesized compounds (ianthelliformisamines A-C and their analogues) were screened for antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains. All synthetic analogues of ianthelliformisamine A showed bacterial growth inhibition against both strains (Escherichia coli and Staphylococcus aureus), having MIC values in the range of 117.8-0.10 μM, while none of the synthetic analogues of ianthelliformisamine C as well as the parent compound showed any detectable antibacterial activity. Interestingly, some of the synthetic analogues of ianthelliformisamines A and B exerted a bactericidal effect against both E. coli and S. aureus strains, decreasing viable bacterial count by 99% at concentrations as low as 2 × MIC. This journal is the Partner Organisations 2014.

Mild and efficient synthesis of N1,N5,N 10-tri-tert-butoxycarbonyl spermine

This article describes a mild and efficient synthesis of N 1,N5,N10-tri-tert-butoxycarbonyl spermine from putrescine, with a 41% overall yield. The key steps include a Michael addition and Raney nickel (W-2) reduction. The advantages of this synthesis include a simple procedure, mild conditions, and good yields. Taylor & Francis Group, LLC.

Polyamine functionalized carbon nanotubes: Synthesis, characterization, cytotoxicity and siRNA binding

In this work we have synthesized a new series of cationic carbon nanotubes (CNTs) for siRNA binding. Both single- and multi-walled CNTs have been modified by addition or amidation reaction with short linear polyamine chains including putrescine, spermidin

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities

A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. All analogues showed growth inhibitory ac

(Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators

The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 overexpression is thought to contribute to the development of cancer. W

Solid-phase synthesis of diamine and polyamine amino acid derivatives as HIV-1 Tat-TAR binding inhibitors

A series of diamine and polyamine derivatives, either free amines or salts (HCl or TFA), of aspartic and glutamic acid were prepared in excellent yields using Rink Amide solid-phase synthesis. The asparagine and glutamine derivatives were all evaluated for their ability to inhibit Tat-TAR binding using a FIGS cellular assay, with the polyamine derivatives exhibiting the most promising binding activity.

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-Trypanosomal drugs

The P2 transporter is a nucleoside transporter which is unique to the protozoan parasite Trypanosoma brucei, the causative organism of Human African Trypanosomasis. The transporter has been shown to bind some structural motifs not recognized by other tran

Sinulamide: An H,K-ATPase inhibitor from a soft coral Sinularia sp.

Sinulamide (1), a new tetraprenylated spermine derivative, has been isolated from a soft coral Sinularia sp. as an H,K-ATPase inhibitor. The structure was assigned on the basis of spectroscopic data and confirmed by a total synthesis.