194853-82-2

Usage

Uses

Used in Pharmaceutical Industry:
1-pyridin-4-yl-1,4-diazepane is used as a building block for the synthesis of various bioactive compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
1-pyridin-4-yl-1,4-diazepane is used in the field of medicinal chemistry for the development of new drugs, leveraging its unique structure and properties to create innovative pharmaceutical agents.

InChI:InChI=1/C10H15N3/c1-4-11-7-9-13(8-1)10-2-5-12-6-3-10/h2-3,5-6,11H,1,4,7-9H2

Upstream product

• 505-66-8 1,4-Diazacycloheptane 
• 626-61-9 4-Chloropyridine 
• 1120-87-2 4-bromopyridin 
• 868065-23-0 4-(4-pyridyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 

Downstream Products

• 492431-39-7 N-[5-chloro-1-[(2,4-dimethoxyphenyl)-sulphonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-(4-pyridyl)homopiperazine-1-carboxamide 
• 714249-12-4 ethyl ({[(7-cyano-2-naphthyl)methyl]{4-[4-(pyridin-4-yl)-1,4-diazepan-1-yl]phenyl}amino}sulfonyl)acetate 
• 220220-31-5 7-[({4-[4-(pyridin-4-yl)-1,4-diazepan-1-yl]phenyl}amino)methyl]-2-naphthonitrile 
• 220220-06-4 1-(4-nitrophenyl)-4-(pyridin-4-yl)-1,4-diazepane 

Relevant academic research and scientific papers

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

Exo-ligands based on two p-aminopyridine interconnection by tuneable alkyl chains: Design, synthesis and structural analysis of silver and palladium metallamacrocycles

Exo-ligands based on functionalisation of diazacyclic cores of variable size by two pyridines has been achieved; under self-assembly conditions, their ability to form metallamacrocycles in the presence of PdII or AgII was demonstrated by X-ray crystallography.