714249-12-4

Upstream product

• 55896-93-0 ethyl 2-(chlorosulfonyl)acetate 
• 220220-31-5 7-[({4-[4-(pyridin-4-yl)-1,4-diazepan-1-yl]phenyl}amino)methyl]-2-naphthonitrile 
• 220220-06-4 1-(4-nitrophenyl)-4-(pyridin-4-yl)-1,4-diazepane 
• 194853-82-2 1-(pyridin-4-yl)-1,4-diazepane 
• 350-46-9 4-Fluoronitrobenzene 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site. Compound 13 (YM-96765) showed potent fXa inhibitory activity (IC50=6.8nM) and effective antithrombotic activity without prolonging bleeding time.