194856-86-5Relevant academic research and scientific papers
Enantioselective hydrogenation of β-keto sulfones with chiral Ru(II)- catalysts: Synthesis of enantiomerically pure butenolides and γ- butyrolactones
Bertus,Phansavath,Ratovelomanana-Vidal,Genet,Touati,Homri,Hassine, B. Ben
, p. 1369 - 1380 (2007/10/03)
A series of β-hydroxy sulfones were synthesized with high enantioselectivities via a new enantioselective ruthenium-catalyzed hydrogenation using MeO-BIPHEP as a ligand. Some β-hydroxy sulfones were used in the synthesis of optically active butenolides and γ-butyrolactones with high yields and enantioselectivities over 95%.
Synthesis of 2-acetylenic carboxylic acids, 1-sulfinyl and 1-sulfonyl- 2-ketones from 2-acetylenic phenyl sulfides
Fortes, Carlos C.,Garrote, Clevia F.D.
, p. 2993 - 3026 (2007/10/03)
Monochlorination at the 1-position with sulfuryl chloride, followed by methanolysis converted 2-acetylenic phenyl sulfides into 1-methoxy-2- acetylenic phenyl sulfides. Oxidation with chromic acid gave 2-acetylenic carboxylic acids. Oxidation of 2-acetylenic phenyl sulfides with Oxone and hydrogen peroxide in acetic acid gave the corresponding sulfoxides and sulfones respectively. Diethylamine addition to the triple bond produced enamines which were hydrolyzed with aqueous hydrochloric acid to the corresponding 1-sulfinyl and 1-sulfonyl-2-ketones.
Enantioselective introduction of a benzenesulfonylmethyl substituent at an unactivated carbon atom via chemoenzymatic methods
Maguire, Anita R.,Kelleher, Leonard L.
, p. 7459 - 7462 (2007/10/03)
Introduction of a benzenesulfonylmethyl group at the unactivated γ-carbon of carboxylic acid derivatives has been achieved through a combination of rhodium acetate catalysed carbenoid C-H insertion and baker's yeast mediated kinetic resolution. Access to
