194864-02-3Relevant articles and documents
A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III
Zhou, Hui,Chen, Dahai,Gao, Hongwei,Li, Qingeng
, p. 450 - 452 (2010)
A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III, utilizi
Method for preparing water-soluble texane derivatives and intermediates
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Paragraph 0130; 0158-0160, (2017/09/02)
The invention discloses a method for preparing texane derivatives of a formula 2, formula 1 compounds which are intermediates or raw materials used for preparing the texane derivatives of the formula 2, and a preparation method of the compounds of the formula 1, wherein the formula 1 and the formula 2 are shown in the description.
TAXANE AND ABEO-TAXANE ANALOGS
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Paragraph 0068; 0092, (2013/07/25)
The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION
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Page/Page column 11-13, (2008/12/04)
The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER
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Page/Page column 8-9, (2008/12/07)
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s
Biologically Active Taxane Analogs and Methods of Treatment
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Page/Page column 11; sheet 5, (2008/12/08)
The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: wherein R
9,10-alpha,alpha-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF
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Page/Page column 38, (2008/06/13)
The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R1 and R2 are each selected fr