194869-14-2

Upstream product

• 60144-52-7 tert-butyl 3-methoxyphenylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 536-90-3 m-Anisidine 

Downstream Products

• 520-53-6 psilocin 
• 3965-97-7 O-Methylpsilocine 
• 1094396-81-2 C₁₅H₂₀INO₃ 
• 1448535-59-8 tert-butyl 2-iodo-3-methoxyphenyl(propionyl)carbamate 
• 1448535-68-9 (E)-tert-butyl 2-iodo-3-methoxyphenyl(prop-1-enyl)carbamate 
• 4837-90-5 4-methoxy-1H-indole 
• 4098-40-2 mitragynine 
• 951327-91-6 (2R,6R,12bS,E)-benzyl 3-ethylidene-8-methoxy-2-(2-methoxy-2-oxoethyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6-carboxylate 
• 951327-86-9 (1S,3R)-benzyl 2-((Z)-2-iodobut-2-enyl)-5-methoxy-1-((E)-4-methoxy-4-oxobut-2-enyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate 
• 951327-90-5 (1S,3R,Z)-benzyl 2-(2-iodobut-2-enyl)-5-methoxy-1-(4-methoxy-4-oxo-3,3-bis(phenylthio)butyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate 
• 951327-85-8 (R,Z)-benzyl 2-(2-iodobut-2-enylamino)-3-(4-methoxy-1H-indol-3-yl)propanoate 
• 951327-89-2 4-methoxy-D-tryptophan benzyl ester 
• 98991-09-4 2-iodo-3-methoxyphenylamine 
• 231620-54-5 [2-(2,5-dimethoxy-2,3-dihydro-furan-3-yl)-3-methoxy-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family

Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural s

Microwave-assisted synthesis of 3-substituted indoles via intramolecular arene-alkene coupling of o-iodoanilino enamines

A generally applicable and high-yielding protocol for the synthesis of 3-substituted indole derivatives is described. Key features include microwave-assisted intramolecular arene-alkene coupling of o-iodoanilino enamines, and expedient synthesis of o-iodo

Total synthesis of argyrins A and e

The total synthesis of argyrins A and E were accomplished using a convergent strategy by condensation of one tripeptide and two dipeptide fragments. The synthesis strategy, which was developed for the protection of peptide fragments and identification of the optimum macrocylization site, can be applied to further synthetic studies involving other members of the argyrin family.

Synthesis of ring-A-substituted tryptophan by a palladium-catalyzed heteroannulation reaction

Coupling of substituted o-iodoanilines with methyl (S)-2-N,N-di-tert- butoxycarbonyl-5-oxo-pentanoate, derived from glutamic acid, in DMF in the presence of palladium acetate and DABCO provides substituted tryptophans in good to excellent yields. Georg Thieme Verlag Stuttgart.

INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME

An indole derivative represented by the following general formula (1) : wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

A new synthesis of psilocin

A new route to the hallucinogenic alkaloid psilocin, isolated from the mushroom species Psilocybe mexicana, has been established.

General and facile synthesis of indoles with oxygen-bearing substituents at the benzene moiety

Indoles with oxygen-bearing substituents such as a methoxy or (triisopropylsilyl)oxy group at all of the positions of the benzene moiety were synthesized by cyclization of tert-butyl methoxy(or (triisopropylsilyl)oxy)-2-((trimethylsilyl)ethynyl)phenyl)carbamates with potassium tert-butoxide in tert-butyl alcohol. The (ethynylphenyl)carbamates were synthesized by the palladium-catalyzed reaction of (trimethylsilyl)acetylene and the corresponding (iodophenyl)carbamates, which were selectively synthesized by directed lithiation of the phenylcarbamates and subsequent iodination.