60144-52-7

Basic information

• Product Name: tert-butyl 3-methoxyphenylcarbamate
• Synonyms: tert-butyl 3-methoxyphenylcarbamate;N-Boc-3-Methoxyaniline;1-(Boc-amino)-3-methoxybenzene;N-Boc-m-anisidine;tert-Butyl (3-methoxyphenyl)
• CAS NO: 60144-52-7
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.27
• Mol File: 60144-52-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 55-60°C
• Flash Point: >110℃
• Appearance: /
• CAS DataBase Reference: tert-butyl 3-methoxyphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-methoxyphenylcarbamate(60144-52-7)
• EPA Substance Registry System: tert-butyl 3-methoxyphenylcarbamate(60144-52-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-52
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 60144-52-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-methoxyphenylcarbamate, also known as 3-Methoxyphenyl N-tert-butyloxycarbonyl-phenylcarbamate, is a chemical compound that is commonly used as a protecting group in organic synthesis. It is a white to light yellow solid with a molecular formula of C14H19NO4 and a molecular weight of 265.30 g/mol. tert-butyl 3-methoxyphenylcarbamate is often used in the pharmaceutical industry and in the synthesis of various organic compounds. It is known for its stability and its ability to protect certain functional groups during chemical reactions. Tert-butyl 3-methoxyphenylcarbamate is also considered to be relatively non-toxic and has low environmental impacts.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 536-90-3 m-Anisidine 
• 2398-37-0 3-methoxyphenyl bromide 
• 4248-19-5 tert-butyl carbazate 
• 1187581-97-0 C₁₇H₂₅NO₅ 
• 1239374-12-9 tert-butyl 3-methoxyphenyl(3-perfluorooctylpropoxy)carbamate 
• 34619-03-9 tert-butyldicarbonate 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 121006-57-3 5-Methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 194869-14-2 N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline 
• 335672-28-1 tert-butyl N-(2-formyl-3-methoxyphenyl)carbamate 
• 327183-29-9 tert-butyl 2-(2-hydroxyethyl)-3-methoxyphenylcarbamate 
• 809231-02-5 (2-bromo-3-methoxyphenyl)carbamic acid tert-butyl ester 
• 98991-09-4 2-iodo-3-methoxyphenylamine 
• 1620683-48-8 tert-butyl allyl(3-methoxyphenyl)carbamate 
• 1620683-32-0 (E)-tert-butyl (3-methoxyphenyl)(3-(p-tolyl)prop-1-en-1-yl)carbamate 
• 136247-94-4 N-(tert-butoxycarbonyl)-6-methoxyanthranilic acid 
• 136248-00-5 <13CO15NH2>-N-(tert-butoxycarbonyl)-6-methoxyanthranilamide 
• 136247-99-9 N-(tert-butoxycarbonyl)-6-methoxyanthranilamide 
• 136247-96-6 2-tert-Butoxycarbonylamino-4-methoxy-benzoic acid 
• 108716-30-9 benzyl (3-methoxyphenyl)carbamate 
• 877671-39-1 tert-butyl (3-methoxy-4-nitrophenyl)carbamate 

Relevant articles and documents

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family

Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural s

Visible-Light-Triggered C-C and C-N Bond Formation by C-S Bond Cleavage of Benzylic Thioethers

The cleavage of sulfidic C-S bonds under visible-light irradiation was harnessed to generate carbocations under neutral conditions and synthesize valuable di- and triarylalkanes as well as benzyl amines. To this end, photoredox catalysis and direct photoinduced C-S bond cleavage are used as complementary approaches and participate in the versatility of the general strategy. Extensive mechanistic studies have demonstrated the diversity of the reaction mechanism at work in these different reactions.

Preparation, characterization and application of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2]·2Cl) as an efficient dicationic ionic catalyst for the N-Boc protection of amines

In this work, 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2]·2Cl), as a novel Br?nsted acidic ionic catalyst is synthesized and characterized using a series of techniques including FT-IR, TGA, DTA, SEM, pH analysis and Hammett acidity function. This substance can significantly catalyze the N-Boc protection of amines without solvent interference at room temperature. The advantages of this manner are chemoselectivity, short reaction times, suitable yields, excellent yields of the products, without solvent interference and ease of preparation as well as reusability of the catalyst.