194870-66-1

Basic information

• Product Name: 4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE
• Synonyms: 4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE
• CAS NO: 194870-66-1
• Molecular Formula: C₁₁H₉F₂NO₂
• Molecular Weight: 225.19
• Mol File: 194870-66-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE(194870-66-1)
• EPA Substance Registry System: 4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE(194870-66-1)

Safety Data

• Hazardous Substances Data: 194870-66-1(Hazardous Substances Data)

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 40594-37-4 (3,4-difluorophenyl)phenylhydrazine hydrochloride 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 3863-11-4 3,4-difluoroaniline 

Relevant articles and documents

Indole derivative and medical application thereof

The invention discloses an indole compound with FABP4/5 inhibitory activity and a preparation method and medical application of the indole compound. The indole compound is a compound of which the structural formula is shown as a formula I, and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula I is a novel FABP4/5 inhibitor and can be used for preparing medicines for preventing or treating FABP4/5 related diseases.

SUBSTITUTED INDOLE COMPOUND

Disclosed is an excellent LXR modulator. A compound represented by the general formula (I): (I) wherein R1, R2, R3 and R4: H, an alkyl which may be substituted, OH, an alkoxy which may be substituted, an amino which may be substituted, a halogeno, a phenyl or the like; R5: H or an alkyl; R6: -COR8 (wherein R8: an alkoxy which may be substituted, a phenyloxy which may be substituted, an amino which may be substituted, or the like), -SO2R9 (wherein R9: an alkyl which may be substituted, a phenyl which may be substituted or a heterocyclyl which may be substituted), or an alkyl which may be substituted; R7: -X2R10 [wherein R10: -COR11 (where R11: OH, an alkoxy which may be substituted or an amino which may be substituted), -SO2R12 (where R12: an alkyl which may be substituted or amino which may be substituted), -N(R13)COR14 (where R13: H or an alkyl which may be substituted; R14: H or an alkyl which may be substituted), -N(R13)SO2R15 (where R13: as defined above; R15: an alkyl which may be substituted) or tetrazol-5-yl; and X2: a single bond or an alkylene which may be substituted]; X1: a methylene which may be substituted; Y1: a phenyl which may be substituted or a heterocyclyl which may be substituted; and Y2: an aryl which may be substituted, a heterocyclyl which may be substituted or the like], or the like.

Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof

A substituted guanidine derivative represented by the general formula: STR1 wherein R1, R2, R3 and R4 are independently a hydrogen atom, an unsubstituted alkyl group, a substituted alkyl group, a halogen atom or

Indole derivatives

The invention releates to indole derivatives of the formula STR1 wherein R 1 to R 4 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl or trifluoromethyl, R 5 and R 6 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl, trifluoromet